Sr. Director, Clinical Pharmacology

CytomX Therapeutics • South San Francisco, CA

9h • Hybrid

About The Position

Sr. Director, Clinical Pharmacology Headquarters Location: South San Francisco, CA, Company relocating to Emeryville, CA Fall of 2026 Candidate Location: Hybrid Travel Required: 5-10% Reports To : Vice President, Clinical Pharmacology Department: Clinical Pharmacology Position Type : Full-time About CytomX Therapeutics: CytomX Therapeutics, Inc. is committed to changing the treatment of cancer with our novel PROBODY® therapeutic platform. Our commitment to transforming lives with safer, more effective therapies is driven by our curiosity and passion for innovation and our belief that by acting with integrity in an honest, respectful, ethical manner, we have the power to change lives. Our workplace embodies collaboration, open communication, celebrating our successes, and holding each other to the highest possible standards. CytomX’s robust and differentiated pipeline comprises therapeutic candidates across multiple treatment modalities including antibody-drug conjugates (“ADCs”), T-cell engagers, and immune modulators such as cytokines. CytomX’s clinical-stage pipeline includes CX-2051 and CX-801. Learn more at www.cytomX.com .

Requirements

• BS (≥20 years), MS (≥17 years), PharmD/PhD (≥ 15 years) in clinical pharmacology or related function in industry
• Experience in oncology or biologics
• Experience supporting late-stage development and registrational programs
• Strong experience in PK/PD, exposure-response, and clinical data interpretation
• Experience supporting dose justification and regulatory deliverables
• Strong ability to lead program-level execution in a matrixed environment
• Proven track record of delivering high-quality regulatory outputs
• Effective communicator with cross-functional teams
• Experience working in biotech or fast-paced environments

Nice To Haves

• Familiarity with biologics and/or oncology

Responsibilities

• Lead clinical pharmacology activities for assigned programs, from Phase 1 through late-stage development
• Execute and deliver PK/PD, exposure-response, and data integration strategies to support dose selection and regimen optimization
• Translate clinical pharmacology insights into clear, actionable recommendations for program teams
• Partner with the VP to align program strategies with overall functional direction
• Lead preparation of clinical pharmacology deliverables for Regulatory submissions, including exposure–response analyses, dose justification, and summaries
• Support regulatory interactions by preparing materials and addressing health authority questions
• Ensure all outputs are high quality, compliant, and submission-ready
• Provide clinical pharmacology input into study design across Phase 1–3 trials
• Support indication expansion cohorts and combination strategies through data-driven insights
• Ensure timely and accurate delivery of clinical pharmacology analyses
• Work closely with Clinical Development, Regulatory Affairs, Biometrics, and Translational Sciences
• Contribute to integrated development plans and support decision-making
• Communicate complex data clearly to cross-functional teams
• Manage external CROs and vendors supporting PK/PD and modeling activities
• Ensure delivery of analyses aligned with timelines and quality expectations
• Maintain strong oversight of outsourced work

Benefits

• A great environment where we work collaboratively, leverage each other’s strengths, and work toward a shared vision with our common goals of doing the best thing for patients.
• A robust and enduring approach to your development and career growth fueled by a strong learning curriculum and career guidance that helps you understand how you can grow your career at CytomX.
• A robust and highly competitive total rewards program that helps you achieve your compensation goals while supporting a great work / life balance.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior