Sr. Associate Scientist, R&D Chemistry, Peptidomimetic Purification

Regeneron Pharmaceuticals•Hawthorne, CA

1d•Onsite

About The Position

We are currently seeking a lab-centric peptide purification chemist to join the R&D (Research & Development) Chemistry group. In this position, they will play a key role in Regeneron’s peptidomimetic antibody-conjugate drug discovery capabilities to enable seamless combination with the company’s existing expertise in biologics and novel genetic medicines. The candidate will drive the purification of peptidomimetic payloads and linker payloads for antibody conjugate drug therapeutics across diverse research areas. Cultural fit with the Regeneron cross-functional teams will be a key driver for success. The R&D Chemistry team is primarily composed of synthetic organic, medicinal chemistry and bioconjugation scientists that work in a highly collaborative environment with other technology, biology and therapeutic area groups. Successful candidates will have a peptide/peptidomimetic purification background and will require a firm understanding of the latest techniques, strategies and instrumentation for HT peptide purification and isolation. We expect they will act as an inspiring and motivating colleague, effective communicator, and strong project team collaborator to help develop novel antibody-conjugated peptidomimetic therapeutics.

Requirements

Bachelor’s degree required, Master’s degree preferred in peptide, peptidomimetic, small molecule purification
Minimum of 5 years of industry experience.
Extensive hands-on experience of the HPLC purification/detection and method troubleshooting of peptidomimetics
Hands-on experience with Waters and/or Agilent purifications systems preferred
Hands-on experience with mass-triggered collection preferred
Extensive experience running modern purification/isolation equipment and instrumentation
A track record of success in the field of either peptidomimetics or small molecules purification is required.
Working collaboratively with both internal and external organizations (e.g., CROs) is essential.

Nice To Haves

Passion and enthusiasm about the promise of peptidomimetic conjugated, antibody-targeted therapeutics and how peptide purification can enable their generation.
You enjoy applying and combining traditional methods and novel technologies to develop solutions for purification.
You are comfortable working in a cross-functional role and excel in a diverse team where egos are checked at the door.
You want to provide meaningful contributions to the development of an organizational culture that supports growth and development of its people and capabilities to drive forward the Regeneron pipeline.
You prefer to work in an organization that is modality agnostic, letting the data determine the best course forward.

Responsibilities

Actively participate and collaborate in the day-to-day activities of the R&D Chemistry Peptidomimetic purification team.
Perform mass-triggered HPLC purification of novel peptidomimetic drug modalities, using modern purification instrumentation/detection and techniques
Troubleshoot and optimize peptide purification methods and enable high throughput purification and isolation.
Identify new strategies and technologies for peptidomimetic purification to improve on existing Regeneron techniques
Actively participate in departmental, cross-functional, leadership, and external meetings to contribute expertise and to represent the vision of the R&D Chemistry Peptidomimetic purification team.
Interact broadly and collaboratively with other Regeneron groups, forging relationships and active collaborations.