Sr. Associate Scientist- Formulation Development

Pfizer • St Louis, MO

13h • Onsite

About The Position

This position will be part of Drug Product Design and Development (DPDD) within the Pharmaceutical Research and Development (PhRD) department. The incumbent will participate in the development of parenteral formulation for biologics modalities such as monoclonal antibodies, peptide-based therapeutics, antibody drug conjugates, proteins, and vaccines. This position will be responsible for performing analytical characterization of candidate molecules by using various biophysical and biochemical characterization techniques. Furthermore, this position will assist in developing processes for drug product manufacturing, responsible for data compilation, data presentations and report writing. Your strong foundation in general scientific practice, its principles and concepts will help in meeting critical deadlines. You will be relied on as a technical contributor to assess the assigned tasks and make decisions that involve direct application of your knowledge. It is your dedication that will make Pfizer ready to achieve new milestones and help patients across the globe.

Requirements

• B.S. in Biochemistry, Chemical/Biochemical Engineering, Pharmacy, Chemistry, Biology, or equivalent with a minimum of 2 years' relevant industry experience.
• Ability to follow established procedures independently is required.
• Working knowledge of SE-UPLC, RP-UPLC, LC-MS, peptide mapping, UPLC (IEX), SDS-PAGE, Capillary Gel electrophoresis (CGE), imaged Capillary Electrophoresis (iCE), spectroscopy techniques.
• Experience with biotherapeutics analytical methods such as UPLC (IEX), SDS-PAGE, Capillary Gel electrophoresis (CGE), imaged Capillary Electrophoresis (iCE), spectroscopy techniques.
• Demonstrated scientific documentation skills.
• Permanent work authorization in the United States.

Nice To Haves

• M.S. Degree in above, and 0-2 years of experience preferred.
• Experience with drug development of biologics and vaccines.
• 2-4 years of hands-on lab experience in analytical techniques.
• Excellent documentation skills.
• Self-motivated and highly effective in a team-based environment.
• Effective written and oral communication skills.
• Familiarity with GMP requirements.
• Familiarity with parenteral manufacturing requirements, container/closure integrity, and clinical and commercial unit operations.
• Practical knowledge of lyophilization and lyophilization cycle development.

Responsibilities

• Participate in developing parenteral formulations for biotherapeutic modalities such as monoclonal antibodies, peptide-based therapeutics, antibody drug conjugates, proteins and vaccines.
• Assist in developing manufacturing processes (under general supervision).
• Perform rapid, comprehensive characterization of candidate molecules to determine the stability profile and applying this information to develop an appropriate dosage form to meet clinical needs.
• Assist in the development and scale-up of drug product processes from bench top to pilot scale and, as required, technology transfer to commercial plants.
• Prepare data summary presentation, compile data and author technical reports.
• Interact effectively with a multi-disciplinary team of scientists for formulation optimization and overall candidate progression.
• Communicate effectively with laboratory scientists, project managers and colleagues from numerous functions, serving on multi-disciplinary project teams.

Benefits

• 401(k) plan with Pfizer Matching Contributions
• Additional Pfizer Retirement Savings Contribution
• Paid vacation, holiday and personal days
• Paid caregiver/parental and medical leave
• Health benefits to include medical, prescription drug, dental and vision coverage
• Relocation assistance may be available

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level