Sr Associate Scientist, Biology

Gilead Sciences • Foster City, CA

1d

About The Position

At Gilead our pursuit of a healthier world for all people has yielded a cure for hepatitis C, revolutionary improvements in HIV treatment and prevention as well as advancements in therapies for viral and inflammatory diseases and certain cancers. We set and achieve bold ambitions in our fight against the world’s most devastating diseases, united in our commitment to confronting the largest public health challenges of our day and improving the lives of patients for generations to come. We are seeking a skilled Sr. Associate Scientist to support pharmacokinetic (PK) bioanalysis of large molecules across discovery and early development programs. This individual will play a key role in independently developing, executing, and troubleshooting high throughput bioanalytical assays, while collaborating closely with cross-functional teams to deliver high-quality data that informs critical project decisions. The ideal candidate thrives in a fast-paced, results-driven environment, demonstrates strong scientific ownership, and is eager to expand their impact beyond core bioanalysis into broader drug discovery efforts.

Requirements

• BS with 5+ years or MS with 3+ years in Pharmaceutical Science, Biochemistry, Biology or related discipline.
• 2–3 years of industry experience in PK bioanalysis, DMPK, or related field
• Hands-on experience independently supporting and executing in vivo PK studies for large molecules (e.g., monoclonal antibodies, peptides, biologics)
• Expertise in ligand-binding assays (ELISA, MSD, Gyrolab), including assay development, optimization, and troubleshooting
• Broad knowledge of PK bioanalytical assays, including ADA
• Demonstrated ability to analyze and interpret PK data, including curve fitting (4PL/5PL), QC evaluation, and trend analysis
• Strong understanding of PK/ADME principles for biologics (AUC, clearance, half-life, TMDD, nonlinear PK)
• Working knowledge of antibody-drug conjugates (ADCs) and their bioanalytical challenges
• Proven ability to design experiments and troubleshoot independently
• Experience working with biological matrices (serum, plasma, tissue)
• Ability to manage multiple studies and timelines
• Strong communication and presentation skills

Nice To Haves

• Experience with LC-MS/MS
• Experience with in vitro high throughput screening technologies
• Familiarity with HTS (96/384/1536-well formats) and laboratory automation

Responsibilities

• Design, develop, and execute bioanalytical assays for large molecules and ADC
• Perform ligand-binding assays (LBA) such as ELISA and MSD in different biological matrices to support PK studies
• Independently analyze and interpret experimental data, and ensure data quality and integrity
• Independently troubleshoot assay performance issues and implement effective solutions
• Manage PK sample analysis workflows across multiple studies
• Collaborate with DMPK, biology, and project teams
• Prepare presentations and written reports
• Maintain accurate documentation
• Contribute to automation and workflow improvements
• Support broader discovery and screening activities

Benefits

• This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package.
• Benefits include company-sponsored medical, dental, vision, and life insurance plans.
• For additional benefits information, visit: https://www.gilead.com/careers/compensation-benefits-and-wellbeing
• Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Number of Employees: 5,001-10,000 employees