Technician I or II – Spacial Omics/MERFISH- Sun Lab (Relocation Assistance Available)
About The Position
The Sun Lab is seeking a highly motivated Spatial Omics Technician to collaborate on research projects focused on understanding cellular communication and organization within tissues using advanced spatial transcriptomics and single-cell genomics technologies. The role involves establishing and scaling MERFISH-based experiments, including probe design, tissue processing, imaging, and data preprocessing. This position offers hands-on training with cutting-edge technologies for early career candidates and opportunities for experienced candidates to optimize workflows and contribute to technology development in collaboration with computational researchers. The successful candidate will support the scientific objectives of the laboratory by performing spatial transcriptomics experiments and associated molecular biology procedures, with a focus on MERFISH and related technologies. They will also support the development, optimization, and execution of imaging-based transcriptomics workflows and associated data preprocessing pipelines, ensuring high-quality experimental data generation that supports computational modeling and biological discovery. Depending on experience level, the technician may contribute to protocol development, computational workflows, and experimental design.
Requirements
- BSc or MSc (or equivalent) in Molecular Biology, Bioengineering, Genomics, Bioinformatics, or a related field
- Experience with molecular biology techniques such as RNA handling, hybridization assays, or microscopy
- Strong organizational and problem-solving skills
- Ability to work independently and collaboratively in an interdisciplinary research environment
- Excellent communication skills and attention to detail
Nice To Haves
- Experience with spatial transcriptomics technologies (e.g., MERFISH, Xenium, Slide-seq, seqFISH, or related platforms) is preferred for more experienced candidates but not required for entry-level
- For Technical Assistant II level candidates: Demonstrated experience independently performing complex molecular biology workflows, troubleshooting experiments, optimizing protocols, and/or working with computational or image analysis pipelines is preferred
- Basic programming or scripting experience (e.g., Python, R, or MATLAB) is preferred
- Experience with image analysis or bioinformatics tools is a plus
Responsibilities
- Perform spatial transcriptomics experiments, including MERFISH sample preparation, hybridization, and imaging workflows
- Prepare tissue samples (e.g., cryosectioning, fixation, staining) for spatial transcriptomics experiments
- Assist with or perform probe design and optimization for MERFISH and related spatial technologies
- Assist with, run, and maintain spatial transcriptomics preprocessing pipelines, including decoding, segmentation, and quality control
- Organize and manage spatial imaging datasets and associated metadata
- Develop, implement or modify or implement scripts for probe design, data preprocessing, and quality assessment, as appropriate based on experience
- Work closely with computational team members to ensure data compatibility with downstream analysis pipelines
- Maintain detailed experimental documentation and protocols
- Present experimental progress and results to lab members and collaborators
- Contribute to the development and optimization of experimental workflows, consistent with experience and level of responsibility
Benefits
- Relocation Assistance Available
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
Education Level
Associate degree
