Senior Vice President, Medical Affairs

Tango Therapeutics•Boston, MA

23d•$372,000 - $558,000

About The Position

Tango Therapeutics is seeking a senior physician leader to define, build, and execute a unified Global and US Medical Affairs strategy as the company transitions from a research-stage biotech into a fully integrated commercial organization. Reporting to the Chief Commercialization Officer (CCO) and serving on the Commercial Leadership Team, the SVP will build and scale the medical infrastructure needed to support launch and lifecycle management of Tango’s precision synthetic lethality oral oncology medicines. The role serves as a strategic bridge among clinical development, regulatory affairs, and commercialization, translating clinical promise into globally aligned scientific narratives that support external engagement, evidence generation, medical education, patient access, and product value. The SVP will lead strategic integration across Global and US Medical Affairs; provide medical partnership and input to clinical development, regulatory, market access, and commercial functions; and represent Tango as a senior scientific voice in US and international markets. The role also oversees field medical strategy, evidence generation including real-world evidence, scientific communications and publications, medical information, medical education, access programs, and medical governance and compliance.

Requirements

Advanced clinical degree required; MD or DO strongly preferred, with PharmD or PhD considered for candidates with exceptional clinical oncology experience.
Specialized clinical training in oncology; board certification preferred.
15+ years of progressive experience in the biopharmaceutical industry, including significant senior Medical Affairs leadership experience at VP level or above, specifically in oncology or precision medicine.
Demonstrated experience designing and executing Medical Affairs strategies on both US and global scales.
Proven track record supporting successful oncology product launches and managing marketed products.
Comprehensive understanding of global clinical development processes, international regulatory environments, and diverse healthcare access landscapes.
Strong business acumen and ability to collaborate with commercial counterparts and translate complex scientific data into strategic corporate initiatives.
Exceptional executive presence, interpersonal, and communication skills, with an established high-level network of global oncology KOL relationships.

Nice To Haves

MD or DO degree.
Board certification in oncology or relevant specialty.
PharmD or PhD, if accompanied by exceptional clinical oncology experience.

Responsibilities

Develop, articulate, and execute an integrated Global and US Medical Affairs strategy aligned with corporate objectives, clinical development plans, and global commercial strategies.
Partner strategically with Clinical Development, Regulatory Affairs, Market Access, and Commercial to support asset development and transition pipeline assets into commercial products.
Provide strategic medical input into global commercial plans, marketing materials, and product positioning, maintaining scientific integrity and alignment with clinical realities.
Use clinical and scientific data and global medical community insights to inform clinical trial design, target product profiles, and lifecycle management plans.
Serve as Tango’s primary physician leader, company spokesperson, and external scientific representative in US and international markets.
Identify, cultivate, and maintain relationships with global and regional oncology KOLs, clinical investigators, health systems, medical societies, and academic institutions.
Provide strategic direction to the US Field Medical team and guide expansion of an international field medical strategy, including scientific exchange, clinical insight gathering, and support for investigator-initiated studies.
Lead global pre-launch, launch, and post-launch evidence generation and oversee real-world evidence strategies supporting the portfolio’s global value proposition.
Oversee the global publication plan, scientific communications strategy, and core global materials, including congress plans, ensuring accurate, timely, and compliant communication of clinical data.
Establish and oversee Medical Information, including accurate and balanced responses to unsolicited inquiries globally.
Manage strategies for continuing medical education and early access or expanded access programs.
Ensure Medical Affairs activities comply with applicable legal, regulatory, and ethical requirements, and provide medical governance oversight for promotional materials.
Recruit, build, scale, and mentor a Medical Affairs organization including field medical, medical information, and HEOR capabilities.