Senior Vice President, Medical Affairs

Tango Therapeutics•Boston, MA

22d

About The Position

Tango Therapeutics is a biotechnology company focused on discovering novel drug targets and developing precision medicines for cancer using the genetic principle of synthetic lethality. Its labs and offices are located at 201 Brookline Avenue in Boston, Massachusetts. The Senior Vice President, Global & US Medical Affairs is an enterprise leader responsible for defining, building, and executing a unified global and US Medical Affairs strategy. As Tango transitions from a research-stage biotech to an integrated commercial organization, this executive will build and scale the medical infrastructure needed to support launches and lifecycle management of precision synthetic lethality oral oncology medicines. Reporting to the Chief Commercialization Officer (CCO) and serving on the Commercial Leadership Team, the role provides senior physician leadership and connects clinical development, regulatory affairs, and commercialization. The SVP will translate clinical evidence into globally aligned scientific narratives and drive external engagement, evidence generation, and medical education to support patient access and product value. The role includes setting integrated medical strategy; partnering across clinical development, regulatory, market access, and commercial functions; informing commercial plans and product positioning; and using clinical data and medical-community insights to shape trial design, target product profiles, and lifecycle plans. The SVP serves as the company’s senior physician spokesperson, develops global and regional oncology KOL relationships, leads US field medical strategy, and guides international field medical expansion. The executive leads global evidence-generation strategies, including HEOR and real-world evidence, and oversees scientific publications, communications, congress plans, medical information, continuing medical education, and early or expanded access programs. The role also provides medical governance oversight and ensures Medical Affairs work complies with applicable legal, regulatory, and ethical requirements. The position requires an advanced clinical degree, substantial progressive biopharmaceutical experience, senior Medical Affairs leadership experience in oncology or precision medicine, and a record of global and US strategy development and oncology product launches. The successful candidate will have experience building and mentoring Medical Affairs teams and strong knowledge of clinical development, regulatory environments, healthcare access, and global oncology relationships.

Requirements

Advanced clinical degree required; MD or DO strongly preferred. PharmD or PhD may be considered with exceptional clinical oncology experience.
Specialized clinical training in oncology; board certification preferred.
15+ years of progressive biopharmaceutical industry experience, including significant senior Medical Affairs leadership experience at VP level or above in oncology or precision medicine.
Demonstrated experience designing and executing Medical Affairs strategies in both US and global markets.
Proven track record supporting successful oncology product launches and managing marketed products.
Experience recruiting, building, scaling, and mentoring a Medical Affairs organization, including field medical, medical information, and HEOR, during a transition from clinical-stage to commercialization.
Comprehensive understanding of global clinical development processes, international regulatory environments, and diverse healthcare access landscapes.
Strong business acumen and ability to collaborate with commercial counterparts and translate complex scientific data into strategic corporate initiatives.
Exceptional executive presence, interpersonal, and communication skills.
Established high-level network of relationships among global oncology KOLs.

Nice To Haves

MD or DO degree.
Board certification in oncology.

Responsibilities

Develop and execute an integrated Global and US Medical Affairs strategy aligned with corporate objectives, clinical development plans, and global commercial strategies.
Partner strategically with Clinical Development, Regulatory Affairs, Market Access, and Commercial to support asset development and the transition of pipeline assets into commercial products.
Provide medical input into global commercial plans, marketing materials, and product positioning to ensure scientific integrity and alignment with clinical realities.
Use clinical and scientific data and insights from the medical community to inform clinical trial design, target product profiles, and lifecycle management plans.
Serve as the primary physician leader, company spokesperson, and external scientific representative in US and international markets.
Build and maintain relationships with global and regional KOLs, clinical investigators, health systems, medical societies, and academic institutions, particularly in oncology.
Provide strategic direction to the US Field Medical team and guide international field medical strategy, scientific exchange, clinical insight gathering, and support for investigator-initiated studies.
Lead global pre-launch, launch, and post-launch evidence-generation strategy, including real-world evidence strategies supporting the portfolio’s global value proposition.
Oversee global publication planning, scientific communications, congress plans, and core global materials, ensuring clinical data are disseminated accurately, promptly, and compliantly.
Establish and oversee Medical Information, including accurate and balanced responses to unsolicited global inquiries.
Manage strategies for continuing medical education and early access or expanded access programs.
Ensure Medical Affairs activities comply with applicable legal, regulatory, and ethical guidelines, and provide medical governance oversight for promotional materials.
Recruit, build, scale, and mentor a Medical Affairs organization, including field medical, medical information, and HEOR capabilities.