Senior Vice President, Chemistry & CMC

Rezo Therapeutics•San Francisco, CA

15d•$270,000 - $370,000

About The Position

Rezo Therapeutics is seeking an accomplished Senior Vice President of Chemistry & CMC to lead medicinal chemistry and transition small-molecule programs from advanced lead optimization through development candidate nomination, IND-enabling development, and clinical readiness. The role combines scientific judgment with practical execution and includes ownership of chemistry strategy across the portfolio, leadership of CMC strategy for nominated candidates, and expansion of Rezo’s chemistry platform for protein complex modulators. The successful candidate will build and develop an internal chemistry organization while leveraging external capabilities, and collaborate with colleagues across biology, structural biology, computational sciences, pharmacology, and company leadership. They will also lead intellectual property strategy and communicate program progress to executive leadership, investors, and the Board. The position is based in San Francisco, California, and is eligible for participation in the company’s Annual Discretionary Bonus Plan and Equity Incentive Plan.

Requirements

PhD in chemistry or a closely related discipline.
Approximately 15–20+ years of relevant pharmaceutical or biotechnology industry experience, with significant progressive leadership responsibility.
Track record of late-stage small-molecule lead optimization and successful development candidate nomination for an oncology indication.
Direct accountability for advancing at least assets through IND-enabling studies.
Strong medicinal chemistry expertise, including optimizing oral exposure of beyond-Rule-of-5 molecules.
Substantive hands-on leadership of small-molecule CMC activities.
Clear, persuasive communication skills and ability to operate strategically and hands-on in a resource-conscious, fast-moving biotech environment.

Responsibilities

Own chemistry strategy and execution across the small-molecule portfolio, particularly late-stage lead optimization, candidate quality, developability, and nomination criteria.
Lead integrated compound optimization using structural and mechanistic insights, pharmacology, DMPK, safety, physicochemical properties, synthetic tractability, and translational objectives; anticipate and resolve program risks.
Drive development candidate selection, including backup strategies and assessment of route scalability, formulation feasibility, and intellectual property.
Lead CMC strategy for nominated candidates through IND-enabling studies and first-in-human readiness, including drug substance, drug product, analytical development, and phase-appropriate control strategies.
Oversee CROs and CDMOs, including partner selection, scopes of work, technical decisions, budgets, quality, risk mitigation, technology transfer, and milestone delivery.
Build, mentor, and develop an internal chemistry organization while leveraging external capabilities; establish a culture of scientific rigor, transparent decision-making, urgency, and accountability.
Collaborate with biology, structural biology, computational sciences, pharmacology, and leadership to integrate emerging data and make portfolio decisions.
Lead expansion of the chemistry platform for identifying and optimizing protein complex modulators.
Lead intellectual property strategy with patent counsel.
Communicate program progress to executive leadership, investors, and the Board.

Benefits

Medical insurance (HMO or PPO)
Dental insurance
Vision insurance
Discretionary time off policy
Company holidays, including summer and winter shutdown
401(k) retirement savings program
Commuter / Mass Transit Benefit Program
Healthcare Flexible Spending Account (FSA)
Dependent care Flexible Spending Account (FSA)
Parental leave
Annual Discretionary Bonus Plan eligibility, based on individual and company performance
Equity Incentive Plan eligibility
Flexible work schedule