Senior Systems Engineer

Veracyte•South San Francisco, CA

16h•$183,000 - $225,000•Hybrid

About The Position

At Veracyte, we offer exciting career opportunities for those interested in joining a pioneering team that is committed to transforming cancer care for patients across the globe. Working at Veracyte enables our employees to not only make a meaningful impact on the lives of patients, but to also learn and grow within a purpose driven environment. This is what we call the Veracyte way – it’s about how we work together, guided by our values, to give clinicians the insights they need to help patients make life-changing decisions. Our Values: We Seek A Better Way: We pursue bold ideas, embrace complexity, and keep pushing forward. We Make It Happen: We act with urgency, deliver with excellence, and always find a way. We Are Stronger Together: We engage with empathy, align around what's best for Veracyte, and celebrate as one team. We Care Deeply: We show up with integrity, kindness, and respect for one another. The Position: The Sr. Systems Engineer is a senior individual contributor and recognized technical authority responsible for the system architecture, reliability, and long-term operability of a commercial in vitro diagnostic (IVD) software product deployed across diverse customer environments. This role is focused exclusively on customer-facing product systems, not internal enterprise IT, and requires deep expertise in Windows-based platforms, distributed systems, and hybrid infrastructure. At the Senior level, this role is expected to operate with broad autonomy and influence, proactively identifying systemic risks, anticipating environment-specific failure modes, and shaping system design decisions early in the product lifecycle. You will partner closely with software engineering, quality, DevOps, and product teams to ensure the product behaves safely, predictably, and reliably across development, validation, and real-world enterprise deployments.

Requirements

Bachelor’s degree in Computer Science, Engineering, or a related field, or equivalent practical experience.
A minimum of 6 – 7 years of experience supporting commercial product software.
Deep hands-on experience with Windows Server environments, including IIS and SQL Server in production.
Strong working knowledge of Linux systems (e.g., Ubuntu, RHEL-based distributions) in product deployments.
Proven experience with Docker and containerized application deployments.
Experience supporting products deployed across virtualized environments (VMware, Hyper-V) and cloud infrastructure.
Hands-on experience with AWS services such as EC2, VPC, IAM, and storage services.
Demonstrated ability to proactively diagnose and resolve complex system-level issues across software, OS, and infrastructure layers.
Experience developing automation scripts using Bash, PowerShell, Python, or similar languages.
Familiarity with CI/CD pipelines and release workflows in regulated or quality-focused environments.
Strong troubleshooting, problem-solving, and communication skills.

Nice To Haves

Direct experience supporting IVD, medical device, or other regulated software products.
Experience maintaining a distributed product for 2–3 years across 100+ enterprise customer installations.
Exposure to container orchestration platforms such as ECS, EKS, or Kubernetes.
Experience with infrastructure as code or configuration management tools.
Familiarity with monitoring and logging platforms and operational diagnostics.
Background in regulated environments with awareness of compliance and audit expectations.
Demonstrated ability to influence system architecture and technical direction at a product level without formal management responsibility.

Responsibilities

Own and evolve the system-level architecture of a Windows-based IVD software product deployed to customer environments.
Act as a system-level technical authority, influencing architecture and design decisions without formal people management.
Design, configure, and support product deployments using IIS, SQL Server, WSL, and Docker across on-premises, virtualized, and cloud environments.
Anticipate, identify, and mitigate environment-specific risks across Windows and Linux systems, virtual machines, containers, networking, and cloud infrastructure.
Support and stabilize a distributed product maintained over multiple years across a large enterprise install base (100+ customer installations).
Lead deep root-cause analysis of complex issues spanning application behavior, operating systems, databases, containers, and infrastructure.
Define, document, and enforce supported deployment models, environment assumptions, constraints, and known failure modes.
Partner early with software engineering to surface non-obvious system dependencies, scalability limits, and operational risks.
Contribute to containerized and orchestrated deployment strategies; experience with ECS or Kubernetes is a plus.
Influence CI/CD pipelines and release processes to improve reliability, repeatability, and diagnosability in regulated environments.
Apply security best practices to product systems, including hardening, access control, patching strategies, and vulnerability management.
Drive improvements in observability through logging, monitoring, diagnostics, and operational tooling.
Develop and maintain automation scripts to reduce manual configuration, increase consistency, and eliminate classes of environment-related issues.
Ensure system designs, configurations, and documentation meet IVD regulatory and quality expectations.
Create and maintain system architecture documentation, deployment guides, and operational playbooks.
Serve as a senior escalation point and mentor for system-level issues, raising the bar for system engineering practices.