Sr Staff Mechanical Engineer

Twist Bioscience•Portland, OR

8d•Hybrid

About The Position

We are seeking a Senior Staff Mechanical Engineer to design, build, and test our next-generation automated wet-lab instruments. Based primarily on-site in Wilsonville, OR with partial remote flexibility, this role requires occasional travel to Twist in South San Francisco, CA and to vendor locations.

Requirements

12+ years of experience as a Senior Mechanical Engineer (or higher) and a 4-year degree in mechanical engineering, or 8 years of experience as a Senior Mechanical Engineer (or higher), with a graduate degree in mechanical engineering
Expert in SolidWorks, with a proven record of delivering end-to-end design packages, complete engineering documentation, and fabrication-ready deliverables.
Lead Mechanical Engineer of at least 2 benchtop or larger instruments that went into Production
Strong experience with robotics/mechatronics and specifying electronic devices
Extensive experience designing hardware for fluidics systems, including custom manifolds and integration of pumps, valves, sensors, regulators, etc.
Proven track record of collaborating with cross-functional teams—including engineers, scientists, and project managers—across the entire project lifecycle, from initial concept to post-release monitoring
Experience managing a CAD PDM system
Excellent communication and writing skills, and the ability to work in a fast-paced team environment
Very strong documentation skills
Comfortable working with evolving requirements and a dynamic work environment driving hardware designs for multiple projects
Proven ability to perform System Integration
Proven ability to perform Systems Testing, including Factory/Site Acceptance Testing

Nice To Haves

Proficiency in 3DExperience
Experience with mechanical design for optical systems
In-depth knowledge and use of machine shop tools (band saws, Mill, drill press, sanders)
Experience performing electrical and electronics troubleshooting
Experience with Altium, Lucid, or other software tools that can be used to create wiring or plumbing diagrams
Experience in specifying device control
Experience compiling and releasing QA documentation
Experience as an Instrument Technical Lead or Instrumentation Systems Engineer

Responsibilities

Use SolidWorks to design multiple instruments that integrate liquid handling, consumable handling, imaging & robotics that meet or exceed System & Hardware requirements
Manage and use SolidWorks AI Agents to create new hardware designs leveraging parts & assemblies already in Twist’s PDM environment
Specify all hardware (off-the-shelf and custom) for the instruments
Work with other team members to develop and refine requirements
Perform tolerance analysis as needed
Support contract manufacturers and vendors as the Mechanical Technical Lead for your designs
Work with other team members to execute and support Factory and Site Acceptance Testing
Compile content and hold multiple design reviews as needed
Use SolidWorks to design & build test fixtures as needed to de-risk concept features or test sub-systems
Support Process Systems Engineers as needed during Concept Development and all other project phases
Provide system fluidics and electrical design documentation
Build, debug, calibrate, and verify the instruments with help from technicians and Process System Engineers
Create full models, part files, part drawings, assembly drawings & a BOM for the System
Maintain full design control and release via 3D- Experience (Dassault Systèmes)
Order & track parts for system builds
Provide updated designs for obsolete parts
Lead hardware design for next-generation custom instrumentation, from concept and feasibility through post-production support.
Provide concept architectures for Roadmap development