Senior Scientist - siRNA Therapeutics

Amgen • Thousand Oaks, CA

1d • $127,122 - $171,988

About The Position

The Senior Scientist will join Amgen’s Genetic Medicines team in Thousand Oaks, California, and generate and implement novel methods to deliver RNA-based therapies to previously unreachable cellular destinations across Amgen’s therapeutic areas. The role focuses on advancing targeted delivery technologies and developing approaches for deploying extrahepatic RNA therapeutics. The scientist will work as a technical and intellectual subject matter expert with disease area, computational biology, and therapeutic development teams, and will communicate findings through presentations and peer-reviewed publications.

Requirements

• Doctorate degree (PhD or PharmD), or a master’s degree and 2 years of relevant scientific experience, or a bachelor’s degree and 4 years of relevant scientific experience.
• Ability to communicate data and recommendations clearly, coordinate with one or more therapeutic areas, and translate project questions into experimental plans.
• Demonstrated independent critical thinking, complex problem solving, and innovative research, evidenced by significant scientific contributions.
• Ability to serve as a subject matter expert and representative on cross-functional project teams.

Nice To Haves

• PhD or master’s degree in molecular biology, cell biology, RNA biology, or a related discipline, with relevant industry or equivalent research experience in oligonucleotide therapeutics and/or genetic medicines.
• Experience performing high-throughput cell-based screening and generating sequencing-based screening data using methods such as Drug-seq, including sample preparation and quality control.
• Experience designing and executing studies of extrahepatic siRNA delivery using antibody-siRNA conjugates and other delivery modalities, including in vivo study design, execution, sample processing, and data interpretation.

Responsibilities

• Help identify and implement new technologies to accelerate discovery in targeted delivery.
• Generate and develop new approaches for deploying extrahepatic RNA therapeutics.
• Collaborate with disease area, computational biology, and therapeutic development teams to make actionable decisions as a technical and intellectual subject matter expert.
• Present research findings to cross-functional groups at internal and external meetings.
• Publish scientific findings in peer-reviewed forums.

Benefits

• Health and welfare plans for staff and eligible dependents, including group medical, dental, and vision coverage.
• Retirement and Savings Plan with company contributions.
• Life and disability insurance.
• Flexible spending accounts.
• Discretionary annual bonus program, or a sales-based incentive plan for field sales representatives.
• Stock-based long-term incentives.
• Award-winning time-off plans.
• Work/life balance and career development opportunities.
• Flexible work models where possible.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior