Senior Scientist: Bispecifics and Antibody Engineering

Regeneron Pharmaceuticals • Tarrytown, GA

11d • $109,900 - $179,300 • Onsite

About The Position

We are seeking a results-driven Senior Scientist to join Regeneron’s Antibody Engineering team within the Bispecifics and Antibody Engineering Department. In this fast-paced, innovative group, you will design, produce, and characterize next-generation antibody and protein therapeutics across multiple therapeutic areas with a focus on myeloid cell biology. Your work will directly contribute to the pipeline and help build new platform capabilities at a pivotal time for antibody engineering.

Requirements

• PhD in molecular biology, cell biology, biochemistry, immunology or a related field with at least one year of relevant experience in academia or industry.
• Core hands-on experience with cloning, antibody expression in mammalian cell lines, antibody purification (i.e., using AKTA systems), and comprehensive protein characterization is desired.

Nice To Haves

• Expertise in myeloid, molecular, and protein biology.
• Learn new skills quickly and troubleshoot antibody production and functional assays effectively.
• Excel in data analysis and interpretation while supporting multiple projects simultaneously.
• Competently prioritize efforts to quickly adapt to evolving program directions.
• Possess exemplary organizational, communication, and presentation skills.
• Enjoy collaborating across diverse, cross-functional teams.
• Familiarity with cell-free expression and structural AI/ML-design is preferred but not required.

Responsibilities

• Apply molecular and structural biology expertise to independently design innovative multi-specific antibodies with desired potency, selectivity and developability.
• Perform molecular and structural-guided design, high-throughput construct generation, and vector engineering using modern software and tools.
• Produce and purify novel and logic-gated alternative format antibodies using mammalian expression systems utilizing an assortment of molecular biology & biochemical techniques (i.e. AKTA systems and other chromatographic columns).
• Characterize binding affinities, binding kinetics & stability.
• Design and implement high-throughput and properly controlled biochemical and cell-based assays (ELISA and AlphaLISA, flow cytometry binding, phagocytic assays, cell activation and cytolytic assays).
• Troubleshoot bioanalytical and cell-based assay data to inform subsequent iterations.
• Engage program stakeholders to communicate biologic designs with data updates to meet program objectives.
• Clearly convey results to management during cross-departmental meetings and maintain timely, accurate entries using Benchling and research ELN.

Benefits

• health and wellness programs (including medical, dental, vision, life, and disability insurance)
• fitness centers
• 401(k) company match
• family support benefits
• equity awards
• annual bonuses
• paid time off
• paid leaves (e.g., military and parental leave)

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree