Senior Scientist, Translational Immunology

Parvus Therapeutics • South San Francisco, CA

2d • Onsite

About The Position

We are seeking a Senior Scientist to join our team and drive projects enabling the translation, validation, and execution of preclinical biomarkers to the clinic.

Requirements

• Bachelors degree with a minimum 10 years of experience or a Masters degree with a minimum of 6 years of experience (at least 2 years must be in biotech or industry setting) in Immunology or other relevant life sciences.
• Experience with regulatory T cells or Tr1 cells will be prioritized.
• Expertise in high-dimensional flow cytometry assays including but not limited to spectral flow cytometry and CyTOF.
• Experience leading phase appropriate clinical bioanalytical assay development and analyses including full validation and management of clinical bioanalytical labs/CROs.
• Experience developing lean and agile clinical biomarker budgets suitable for early phase POC and POM studies.

Nice To Haves

• Experience with nanomedicine
• Experience with IQOQ
• Familiarity with biomarker-centric platforms such as spatial profiling, multi-omics integration
• Excellent oral, written communication, and presentation skills.
• Demonstrated ability to effectively work in cross-functional teams, meet deadlines, and prioritize multiple projects is required.
• Comfortable working collaboratively in a small, fast-paced environment.
• Ability to quickly adjust to shifting project demands and priorities.

Responsibilities

• Identify and validate biomarkers relevant to the pharmacology of target clinical candidates.
• Lead context-of-use validation (in-house or through CLIA-certified laboratories or clinical CROs) of clinical biomarker assays suitable for use in recommended phase 2 dosing selection and/or regulatory submission.
• Write and amend internal SOPs and reports as necessary for GSP or GCLP purposes.
• Liaise with nonclinical pharmacology and discovery immunology teams to establish proof-of-concept/proof-of-mechanism biomarker strategies suitable for use in NHPs and FIH studies.
• Participate in all aspects of lab operation, training, and compliance including external audits where applicable.
• Other duties and responsibilities as assigned.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior