Senior Scientist, Synthetic Purification (On-site)
About The Position
Our Research Scientists are inventors who identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Using innovative thinking, state-of-the-art facilities, and robust scientific methodology, they collaborate to discover medical breakthroughs. As a Senior Scientist in the multiscale separations team within the Separations Sciences team of Analytical Enabling Capabilities, you will work collaboratively to advance the development pipeline. You will primarily perform chromatographic isolation of pharmaceutical APIs and impurities from analytical scale through semi-prep and prep scale, covering small molecules, peptides, conjugate-based modalities, and emerging modalities in the portfolio. You will partner with process chemists and analytical scientists to deploy efficient, fit-for-purpose chemical isolation methods, establish innovative purification workflows, and deliver high-purity materials to accelerate development of medicines and vaccines.
Requirements
- Ph.D. in Synthetic Chemistry, Natural Product Chemistry, Analytical Chemistry, or a related field; alternatively, an M.S. with at least 5 years of experience in the biopharmaceutical industry.
- Experience with analytical, semi-prep, and prep scale chromatography technologies, instrumentation, and workflows, including RPLC, NPLC, and SFC.
- Demonstrated experience applying chromatography to chiral and achiral isolation of challenging pharmaceutical mixtures across modalities, including small molecules, peptides, antibody-drug conjugates, and vaccine adjuvants.
- Experience with mass spectrometry and its application in MS-directed chromatographic purification.
- Working knowledge of orthogonal detection technologies, including PDA, multi-angle light scattering, and charged aerosol detection.
- Creative problem-solving ability in scientific research and development, with a demonstrated record of translating R&D problem-solving into impactful pipeline deliveries.
- External scientific engagement, which may include publications, industry white paper contributions, or presentations at scientific meetings.
- Excellent scientific writing and verbal communication skills.
Nice To Haves
- Experience working in the biopharmaceutical industry as a postdoctoral researcher or intern.
Responsibilities
- Perform chromatographic isolation of pharmaceutical APIs and impurities from analytical scale through semi-prep and prep scale.
- Support purification across small molecules, peptides, conjugate-based modalities, and emerging modalities.
- Partner with process chemists and analytical scientists to deploy efficient, fit-for-purpose chemical isolation methods.
- Establish innovative purification workflows and deliver high-purity materials.
- Apply scientific problem-solving to support development-pipeline delivery.
Benefits
- Medical, dental, and vision healthcare benefits
- Other insurance benefits for employees and their families
- Retirement benefits, including 401(k)
- Paid holidays
- Vacation
- Compassionate and sick days
- Annual bonus eligibility
- Long-term incentive eligibility, if applicable
Stand Out From the Crowd
Upload your resume and get instant feedback on how well it matches this job.
What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
