Senior Scientist, Synthetic Purification (On-site)
About The Position
The Senior Scientist will join the multiscale separations team within the Separations Sciences team of Analytical Enabling Capabilities. The role primarily involves chromatographic isolation of pharmaceutical active pharmaceutical ingredients (APIs) and impurities, from analytical scale through semi-preparative and preparative scale. Work spans small molecules, peptides, conjugate-based modalities, and emerging modalities in the portfolio. The scientist will collaborate with process chemists and analytical scientists to develop efficient, fit-for-purpose chemical isolation methods, establish innovative purification workflows, and deliver high-purity materials to support development of medicines and vaccines. This work takes place in a highly collaborative team focused on advancing the development pipeline.
Requirements
- Ph.D. in Synthetic Chemistry, Natural Product Chemistry, Analytical Chemistry, or a related field, or an M.S. with at least 5 years of experience in the biopharmaceutical industry.
- Experience with analytical, semi-preparative, and preparative-scale chromatography, including RPLC, NPLC, and SFC technologies, instrumentation, and workflows.
- Demonstrated experience applying chromatography to chiral and achiral isolation of challenging pharmaceutical mixtures across modalities, including small molecules, peptides, antibody-drug conjugates, and vaccine adjuvants.
- Experience with mass spectrometry and its application in MS-directed chromatographic purification.
- Working knowledge of orthogonal detection technologies, including PDA, multi-angle light scattering, and charged aerosol detection.
- Creative problem-solving ability in scientific research and development, with a track record of translating R&D problem-solving into impactful pipeline deliveries.
- External scientific engagement, which may include publications, industry white-paper contributions, or presentations at scientific meetings.
- Excellent scientific writing and verbal communication skills.
Nice To Haves
- Experience working in the biopharmaceutical industry as a postdoctoral researcher or intern.
Responsibilities
- Perform chromatographic isolation of pharmaceutical APIs and impurities from analytical scale to semi-preparative and preparative scale.
- Support isolation and purification across small molecules, peptides, conjugate-based modalities, and emerging modalities.
- Partner with process chemists and analytical scientists to deploy efficient, fit-for-purpose chemical isolation methods.
- Establish innovative purification workflows and deliver high-purity materials.
- Apply scientific problem-solving to support advancement of the development pipeline.
Benefits
- Medical insurance
- Dental insurance
- Vision insurance
- Other insurance benefits for employees and family
- Retirement benefits, including a 401(k)
- Paid holidays
- Vacation
- Compassionate days
- Sick days
- Annual bonus eligibility
- Long-term incentive eligibility, if applicable
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
