Senior Scientist, Synthetic Enabling Technologies

Sanofi•Cambridge, MA

1d•Onsite

About The Position

The Process Chemistry team, part of the CMC Synthetics organization within Sanofi R&D, is responsible for the design and preliminary process development of commercial manufacturing routes for drug substances undergoing clinical development. This role focuses on developing new synthetic routes, concepts, and technologies to provide drug substances in the most efficient, robust, economical, environmentally benign, and intrinsically safe way. The Senior Scientist will perform and oversee multi-step route evaluation and route development activities, aiming to establish commercial drug substance manufacturing processes through management and execution of internal and outsourced laboratory activities. This role may also oversee the activities of one or more collaborators. The team is part of Specialty Care, focusing on transforming care for people with immune challenges, rare diseases, cancers, and neurological conditions.

Requirements

Ph.D. in organic or synthetic chemistry.
Strong publication record in peer-reviewed journals (at least one publication in a high-tier journal)
Proficiency with Microsoft suite.
Familiarity with digital tools (e.g. Scifinder-n, and Reaxys) and advanced data analysis software (e.g. Spotfire).

Nice To Haves

Knowledge in at least one of the following areas: advanced analytics, flow chemistry, high throughput experimentation.
Experience in chemocatalysis or biocatalysis including characterization of catalytic processes and/or mechanistic analysis.
Computational capabilities and basic coding skills.
Post-doctoral experience.
Design of experiment, statistical and/or thermo-kinetic modeling.
French language skills

Responsibilities

Design novel synthetic pathway for drug substances in clinical development.
Conduct route scouting in laboratory to demonstrate synthetic viability.
Use all imaginable chemistry tools and methods to develop new synthetic pathways (photochemistry, biochemistry, flow chemistry, electrochemistry, on-line analysis, High Throughput Screening, structural analysis (NMR, UPLC/MS).
Analyze experimental data to drive synthetic experimental plans.
Assist in the design, planning and execution of multi-step experimental studies guided by risk assessment to deliver safe, efficient, robust and scalable drug substance manufacturing processes.
Investigate optimization and scale-up of reaction and purification unit operations.
Collaborate within project teams by working closely with analytical chemists, process engineers, pilot plant experts and project managers within the CMC Synthetics organization.
Communicate scientific results in a clear, concise, and accurate manner via electronic laboratory notebook documentation, development reports, project discussions and presentations.
Draft and review technical reports, external publications and patent applications.
May include management of outsourced laboratory activities: generating scope of work, supervising activities at CDMOs, validating reports for outsourced activities.