Senior Scientist - Small Molecule and Oligonucleotide Process Sciences
About The Position
As a successful candidate you will join the sgRNA Process Development Group as part of the larger Oligonucleotide and Lipid Process Sciences team within Technical Operations/CMC. As SME for the sgRNA upstream process and process chemistry you will be providing technical and operational support across all life-cycle stages for Intellia’s assets from emerging pipeline through commercial-stage activities. You will help drive process design, development, characterization and finally tech transfer of GMP-ready processes while serving as a key technical partner across cross-functional teams within Intellia and with external partners as needed. In this role you are expected to mentor junior staff and drive continuous improvement across our processes and operations.
Requirements
- Solid expertise in phosphoramidite and oligonucleotide process chemistry with hands-on experience in automated synthesizers (OP100, Oligosynt platforms) and HPLC
- Strong organic chemistry foundation with working knowledge in small molecule manufacturing processes is an advantage
- Proficiency in HPLC and LC-MS for oligonucleotide characterization and analytical troubleshooting
- Excellent technical writing skills; track record of authoring SOPs, reports, and regulatory documents.
- Being highly organized with ability to manage multiple concurrent workstreams and drive priorities independently
- PhD in Organic Chemistry, Biochemistry, Biotechnology, or related field
- MS or BS in a related scientific discipline
- Ph.D. or M.S. in Chemistry, Organic Chemistry, Nucleoside Chemistry or related discipline with minimum 2 (PhD) or 8 (M.S.) years' experience, preferably in oligonucleotide field.
- Hands-on experience with solid-phase oligonucleotide synthesis and operation of lab-scale synthesizers; familiarity with GxP operations, quality systems and the pharmaceutical development lifecycle
- Experience driving multiple workstreams internally with cross-functional stakeholders as well as with external partners
Responsibilities
- Lead development, optimization and characterization of solid-phase oligonucleotide synthesis (upstream focus), with emphasis on scalability and tech. transfer (OP100 scale)
- Design and execute process characterization studies/DoEs and troubleshoot analytical data
- Support downstream purification processes to improve yield, purity, and reproducibility
- Support MSAT team with tech transfer and process validation activities as well as continuous process verification as needed
- Track milestones, dependencies, and risks across concurrent PD workstreams
- Manage day-to-day lab resourcing and prioritization
- Coordinate with external manufacturing & supply chain as well as CDMOs in support sgRNA and lipid manufacturing as needed
- Author and review SOPs, batch records, development reports, sections for regulatory filings as well as process validation and change control documentation
- Represent Process Development and provide updates to cross-functional teams using effective communication to both technical and non-technical audiences
- Serve as the team process chemistry SME across the matrix for oligonucleotide and small molecule synthesis; mentor and train junior scientists; and collaborate with stakeholders that support other modalities.
Benefits
- performance-based annual cash bonus
- new hire equity grant
- eligibility to be considered for annual equity awards
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What This Job Offers
Job Type
Full-time
Career Level
Senior
