Senior Scientist - Small Molecule and Oligonucleotide Process Sciences

Intellia Therapeutics, Inc.•Cambridge, MA

7d•$136,800 - $167,200•Onsite

About The Position

Intellia is seeking a Senior Scientist to join the sgRNA Process Development Group within the Oligonucleotide and Lipid Process Sciences team in Technical Operations/CMC. As a Subject Matter Expert (SME) for the sgRNA upstream process and process chemistry, you will provide technical and operational support across all life-cycle stages for Intellia’s assets, from emerging pipeline through commercial-stage activities. You will drive process design, development, characterization, and tech transfer of GMP-ready processes, acting as a key technical partner for cross-functional teams within Intellia and with external partners. This role also involves mentoring junior staff and driving continuous improvement in processes and operations.

Requirements

Solid expertise in phosphoramidite and oligonucleotide process chemistry.
Hands-on experience in automated synthesizers (OP100, Oligosynt platforms) and HPLC.
Strong organic chemistry foundation.
Proficiency in HPLC and LC-MS for oligonucleotide characterization and analytical troubleshooting.
Excellent technical writing skills; track record of authoring SOPs, reports, and regulatory documents.
Highly organized with the ability to manage multiple concurrent workstreams and drive priorities independently.
PhD in Organic Chemistry, Biochemistry, Biotechnology, or related field OR MS or BS in a related scientific discipline.
Ph.D. or M.S. in Chemistry, Organic Chemistry, Nucleoside Chemistry or related discipline with minimum 2 (PhD) or 8 (M.S.) years' experience, preferably in oligonucleotide field.
Hands-on experience with solid-phase oligonucleotide synthesis and operation of lab-scale synthesizers.
Familiarity with GxP operations, quality systems, and the pharmaceutical development lifecycle.
Experience driving multiple workstreams internally with cross-functional stakeholders as well as with external partners.

Nice To Haves

Working knowledge in small molecule manufacturing processes is an advantage.

Responsibilities

Lead development, optimization, and characterization of solid-phase oligonucleotide synthesis (upstream focus), with emphasis on scalability and tech transfer (OP100 scale).
Design and execute process characterization studies/DoEs and troubleshoot analytical data.
Support downstream purification processes to improve yield, purity, and reproducibility.
Support MSAT team with tech transfer and process validation activities, as well as continuous process verification.
Track milestones, dependencies, and risks across concurrent PD workstreams.
Manage day-to-day lab resourcing and prioritization.
Coordinate with external manufacturing & supply chain, as well as CDMOs, in support of sgRNA and lipid manufacturing.
Author and review SOPs, batch records, development reports, sections for regulatory filings, and process validation and change control documentation.
Represent Process Development and provide updates to cross-functional teams using effective communication to both technical and non-technical audiences.
Serve as the team's process chemistry SME across the matrix for oligonucleotide and small molecule synthesis; mentor and train junior scientists; and collaborate with stakeholders supporting other modalities.