Senior Scientist, Respiratory Biology (Discovery Research)
About The Position
The Senior Scientist will join the Respiratory Biology Discovery group and contribute to target identification, target validation, translational biology, and mechanism-of-action studies supporting early discovery programs in chronic lung diseases, including COPD, bronchiectasis, asthma, pulmonary fibrosis, and inflammatory airway diseases. The successful candidate will leverage human-relevant in vitro, ex vivo, and translational experimental systems, with a particular emphasis on primary airway and alveolar epithelial biology, epithelial-stromal and immune-stromal interactions, tissue remodeling, fibrosis, regeneration, and biomarker discovery. The Senior Scientist will generate high-quality mechanistic datasets that inform target prioritization and program decisions and will collaborate closely within multidisciplinary discovery and translational teams.
Requirements
- Bachelor's (with 7+ years), Master's (with 4+ years) or Ph.D. biology, immunology, pharmacology, physiology, pulmonary biology or related discipline and relevant experience
- Demonstrated expertise in respiratory biology and human primary cell culture systems, including airway and/or alveolar epithelial models
- Experience developing and applying disease-relevant in vitro and ex vivo systems such as ALI cultures, organoids, co-culture models, or precision-cut lung slices
- Strong hands-on experience in molecular and cellular biology techniques
- Experience with flow cytometry/FACS, imaging-based approaches (IHC, IF, ICC, confocal microscopy), image analysis, and multiplex biomarker platforms (Meso Scale Discovery, Luminex, Olink, AlphaLISA or equivalent)
- Experience supporting translational biology, target validation, and mechanism-of-action studies
- Ability to independently design, execute, troubleshoot, and interpret experimental studies
- Strong scientific communication skills and ability to present findings in cross-functional settings
Nice To Haves
- Prior experience in respiratory drug discovery, fibrosis, tissue remodeling, regenerative biology, or inflammatory lung disease research
- Experience with macrophage, fibroblast, epithelial, or immune-stromal co-culture systems
- Experience working with patient-derived respiratory tissues and primary human lung cells
- Familiarity with transcriptomic datasets including bulk RNA-seq and single-cell RNA-seq
- Experience with organoid biology, human tissue-based models, or spatial biology approaches
- Knowledge of translational biomarker strategies and human disease-relevant endpoints
Responsibilities
- Design, execute, and interpret in vitro and ex vivo studies to support respiratory target discovery, validation and translational biology programs.
- Develop and apply disease‑relevant experimental systems, including primary airway epithelial cultures, air‑liquid interface (ALI) models, organoid systems, precision-cut lung slices (PCLS), and co-culture platforms.
- Generate mechanistic datasets to investigate epithelial dysfunction, tissue remodeling, fibrosis, immune responses, and regenerative biology in chronic lung diseases.
- Apply imaging techniques, including immunohistochemistry (IHC), immunofluorescence (IF), and high‑content imaging, with image‑based analysis to interrogate disease-relevant biology.
- Perform and interpret flow cytometry/FACS‑based immune and cell phenotyping.
- Support translational biomarker discovery and validation using patient-derived samples and multiplex biomarker platforms (Meso Scale Discovery, Luminex, Olink, AlphaLISA).
- Integrate cellular, molecular, imaging, and biomarker datasets to inform project decisions and translational strategies.
- Generate reproducible, high-quality data packages and communicate findings through presentations, technical reports, and cross-functional discussions.
- Collaborate closely across biology, pharmacology, DMPK, and translational and clinical teams within a matrixed discovery environment.
Benefits
- medical, dental, vision healthcare and other insurance benefits (for employee and family)
- retirement benefits, including 401(k)
- paid holidays, vacation, and compassionate and sick days
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
