Senior Scientist, Protein Therapeutics

Gilead Sciences•Foster City, CA

1d•$169,320 - $219,120•Onsite

About The Position

The Senior Scientist, Protein Therapeutics will strengthen Gilead’s Antibody Drug Conjugate (ADC) analytics capabilities and help establish analytical support for a growing portfolio of programs in oncology, inflammation, and virology. This collaborative, laboratory-based role applies expertise in mass spectrometry, protein analytics, and developability assessment to provide scientific insights across ADC projects and teams. The position is based in Foster City, California, and requires onsite work.

Requirements

Bachelor’s degree and 8 years of experience, or master’s degree and 6 years of experience, or PhD and 2 years of experience.
Expertise in mass spectrometry, protein analytics, and developability assessment.
Strong critical-thinking, experimental-design, troubleshooting, and problem-solving skills.
Strong written and verbal communication skills, including the ability to communicate complex scientific concepts to multidisciplinary teams and senior leadership.

Nice To Haves

Degree in analytical chemistry, biochemistry, chemistry, pharmaceutical sciences, or a related discipline.
Preferred experience of 15+ years with a bachelor’s degree, 12+ years with a master’s degree, or 3+ years with a PhD, including postdoctoral training.
Industry experience supporting ADC discovery or development programs.
Deep expertise in protein and ADC analytical characterization, including native and denaturing LC-MS mass analysis, peptide mapping, HIC, SEC, RP, IEX, CE-SDS, and cIEF.
Strong experience with ADC developability assessment workflows.
Experience with multidimensional chromatography approaches for biologics and ADCs, such as HIC-RP-MS, SEC-RP-MS, IEX-RP-MS, or related platforms.
Experience with a variety of conjugation technologies and linker-payload platforms.
Knowledge of ADC pharmacokinetics, metabolism, and bioanalytical considerations, including assessment of circulating ADC species and payload-related biotransformation.
Experience applying analytical, biophysical, and computational data to molecule optimization and predictive developability assessments.

Responsibilities

Independently design and execute analytical characterization experiments for ADCs to support discovery and candidate selection.
Develop, optimize, and troubleshoot advanced analytical methods, including high-resolution LC-MS, intact and subunit mass analysis, peptide mapping, multidimensional chromatography, and plate-based workflows.
Evaluate ADC attributes, including drug-to-antibody ratio (DAR), aggregation, fragmentation, hydrophobicity, charge heterogeneity, and linker-payload stability; integrate analytical and developability data to identify risks and support progression decisions.
Apply scientific judgment to resolve complex analytical challenges and select appropriate experimental approaches for novel and technically challenging assignments.
Evaluate, implement, and advance emerging analytical technologies and workflows to expand ADC characterization capabilities and improve efficiency.
Promote ADC characterization best practices and ensure high-quality experimental design, data integrity, and documentation in accordance with ELN, data management, and data-capturing requirements.
Present scientific findings, conclusions, and recommendations to cross-functional teams.
Contribute to scientific publications, patents, technical reports, and external scientific engagement where appropriate.
Mentor junior scientists and foster a collaborative, innovative, and scientifically rigorous team environment.
Model inclusion, develop and coach employees, align teams with organizational goals, and provide support to remove barriers.