Senior Scientist, siRNA Therapeutics & Delivery

AbbVie•Cambridge, MA

1d•$109,500 - $208,500•Onsite

About The Position

AbbVie is looking for a Senior Scientist I/II to join our siRNA group within the Biotherapeutics and Genetic Medicine (BGM) department. This role will involve designing and executing innovative experimental approaches to address key scientific challenges related to oligonucleotide therapeutics and to enable siRNA delivery for extrahepatic pipeline development. The successful candidate will drive scientific innovation, identify new methods and techniques, and collaborate across functions to support the development of novel RNA-based therapies.

Requirements

BS, MS, or PhD in molecular biology, RNA biology, cell biology, pharmaceutical sciences, biomedical engineering, or or a related scientific discipline, with typically 0-4+ (PhD), 8-10+ (MS), or 10-12+ (BS) years of relevant experience.
Hands-on experience in designing and executing in vitro and in vivo studies to evaluate siRNA delivery platforms, including assessments of cellular uptake, target knockdown, delivery efficiency and biodistribution.
Demonstrated expertise in siRNA therapeutics, including the design, development, characterization and optimization of siRNA sequences and delivery systems.
Extensive hands-on experience and techniques for molecular and RNA biology, including cell culture, RNA extraction, RNA quantification (RT-PCR, qPCR, ddPCR), next-generation sequencing (NGS), protein quantification (ELISA, Western Blot, JESS), flow cytometry and other biomarker quantification.
Proven ability to develop, troubleshoot and refine assays to enhance sensitivity, reproducibility, and throughput.
Highly self-motivated and capable of thriving in a fast-paced, collaborative team environment.
Strong written and verbal communication skills, with experience contributing to technical reports, publications, or regulatory documentation.

Nice To Haves

Proven experience with siRNA and antibody-oligo-conjugates (AOCs) is highly desirable.

Responsibilities

Lead research efforts within a cross-functional team to advance siRNA therapeutics development for ex-hepatic pipelines
Design, evaluate, and develop novel ex-hepatic siRNA delivery platforms for targeted delivery to tissues of interest
Conceive and execute proof-of-concept experiments to validate scientific hypotheses and address technical challenges with high-quality results.
Develop in vitro, ex vivo, and in vivo assays to assess siRNA candidates and delivery technologies in support of program objectives.
Work independently and maintain a high level of productivity in the laboratory, ensuring efficiency and scientific rigor.
Analyze and interpret multidisciplinary data to generate actionable conclusions and guide future experimental directions.
Acquire deep knowledge of RNA biology and siRNA therapeutics to support programs across multiple stages of development.
Collaborate and effectively communicate results with key stakeholders and cross-functional teams throughout the organization.
Contribute as a primary author to scientific publications, presentations, and/or as a primary inventor of patent applications.
Mentor and support junior scientists within the team.