Senior Scientist, Process Chemistry

ORIC Pharmaceuticals • South San Francisco, CA

13h

About The Position

ORIC Pharmaceuticals is a clinical stage biopharmaceutical company dedicated to improving patients’ lives by Overcoming Resistance In Cancer. ORIC’s clinical stage product candidates include (1) ORIC-944, an allosteric inhibitor of the polycomb repressive complex 2 (PRC2) via the EED subunit, being developed for prostate cancer, and (2) ORIC-114, a brain penetrant inhibitor that selectively targets EGFR exon 20, HER2 exon 20 and EGFR atypical mutations, being developed across multiple genetically defined cancers. Beyond these two product candidates, ORIC® is also developing multiple precision medicines targeting other hallmark cancer resistance mechanisms. ORIC has offices in South San Francisco and San Diego, California. We are seeking a highly motivated process development and chemistry senior scientist. This senior scientist designs and executes multi-step experimental studies, utilizing analytical tools to ensure safe and scalable processes. They collaborate cross-functionally, author technical reports, and facilitate the transfer of technology for GMP manufacturing.

Requirements

• PhD in organic chemistry with at least 3 years for Senior Scientist and with 0-2 years’ experience for a scientist of relevant hands-on pharmaceutical/biotech industry experience in the field of new drug development.
• Proven track record for solving process chemistry problems, including identification, optimization, and characterization of robust and scalable synthetic routes.
• Firm understanding of mechanistic organic chemistry.
• Working understanding of analytical tools used in process development (DSC, TGA, DVS, HPLC, NMR, KF, PLM, XRPD).
• Able to work as part of a team with strong interpersonal skills.
• Excellent oral and written communication skills.
• Succinct but thorough communication skills with attention to detail, analytical/critical thinking, and data organization, presentation, and inference.
• Demonstrated passion, curiosity, and enthusiasm in pursuing ideas and solutions despite challenges.
• Demonstrated initiative, ownership, problem identification, problem solving, and strategic thinking.
• Experience writing research reports and detailed reaction procedures.
• Demonstrated ability to work independently and efficiently in a collaborative, fast-paced, integrated, multidisciplinary team.
• Consistent demonstrated high performance, above and beyond the minimum expectations and needs.
• Scientific excellence is demonstrated by publications, presentations, and leadership/engagement in the scientific/professional community.
• Awareness and understanding of ICH, GMP, and regulatory guidance that are important to consider in new drug development.

Responsibilities

• Design, planning, and execution of multi-step experimental studies to provide safe, efficient, robust and scalable processes.
• Independently use PAT and analytical tools and interpret data to gain reaction understanding.
• Share literature and available resources to support relevant precedent for process research.
• Perform experiments and interpret data (calorimetry, TGA, DSC) to safely scale reactions.
• Author development reports and technical packages, and author/review relevant sections in health authority filings (including INDs, NDAs, annual reports, and any other regulatory interactions) and patents.
• Prepare presentation materials and clearly communicate research results to manager, and at internal/external meetings.
• Working cross-functionally with Analytical and Formulations Development colleagues.
• Tech transfer to CMO and scale-up of chemistry, including supporting GMP manufacture.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree