About The Position
The Senior Scientist/Principal Scientist, Oligonucleotide Chemistry will lead the development and execution of chemically modified oligonucleotides (siRNA/ASO and next-generation modalities) to support in vitro and in vivo programs. This role will manage external CROs for oligo synthesis and QC, own and maintain the oligonucleotide database, and drive novel chemistry innovation including advanced modifications and bispecific siRNA formats. This role will work in close collaboration with an internal bioinformatician who designs oligo sequences, with primary responsibility for chemical modification strategy, manufacturability, and chemistry-driven optimization. The role will also collaborate with the IP team to support invention disclosures and patent filings for novel chemistries.
Requirements
- PhD in Chemistry/Chemical Engineering (or related field) with significant experience, or BS/MS with extensive years experience in oligonucleotide chemistry
- Strong experience in chemically modified oligonucleotide synthesis, purification, and characterization
- Hands-on knowledge of oligo synthesis and analytical platforms (e.g., OligoPilot, MerMade, Dr. Oligo, Expedite, HPLC, LC-MS)
- Experience managing CROs and delivering high-quality oligo materials on timelines
Responsibilities
- Lead and optimize chemical modification strategies for oligonucleotides used in in vitro and in vivo studies
- Oversee CROs producing oligonucleotides (scope, timelines, troubleshooting, QC/release review)
- Own and maintain the oligonucleotide database (sequence/modification tracking, lot history, QC documentation, traceability)
- Drive novel chemistry innovation (modifications, linkers, conjugation strategies, delivery-enabling chemistries)
- Support development of bispecific siRNA and other complex oligo architectures
- Collaborate cross-functionally with biology, bioinformatics, and program teams to ensure high-quality delivery of oligo materials
- Partner with the IP/legal team to document innovations and support patent filings (invention disclosures, data summaries, chemistry descriptions)
- Review and interpret analytical data (HPLC, LC-MS) and ensure fit-for-purpose QC standards
- Identify process improvements for better yield, purity, turnaround times and lower cost of goods
- Establish in house capabilities for small and medium scale oligo platform
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
Ph.D. or professional degree
Number of Employees
11-50 employees
