Senior Scientist / Principal Scientist – Translational Medicine, Oligonucleotide Research

Alloy Therapeutics•Waltham, MA

2d•$145,000 - $170,000•Onsite

About The Position

We are Alloy Therapeutics—a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners, we democratize access to pre-competitive tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. The company facilitates affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma. At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. As a reflection of our relentless commitment to the scientific community, we reinvest 100% of our revenue in innovation and access to innovation. MAY THE BEST DRUG WIN. Alloy is headquartered in Waltham, MA with additional labs in Cambridge, UK; Basel, Switzerland, and Athens, GA. Successful members thrive in our shared culture of accountability, deliberate trust, and open communication. As a team we aspire to work together to exceed expectations and collectively contribute across the global organization to always maintain our nimble, startup culture. This is an on-site and full-time position in Waltham, MA. At Alloy, we have an ethos of “Mentorship-By-Apprenticeship” in all of our positions. We strive to have workers in the office when needed to interact organically and face-to-face. Of course, as a lab-based operation, our cells and animals grow 7 days a week, 365 days per year. We respect and value our colleagues for their hard work that requires them to be in the lab every day. We ask our people who have more flexible accommodations, like this position, to appreciate their colleagues who have less flexibility. We are all one team! The Alloy RNA Medicines group is innovating a novel RNA-based drug discovery platform, namely "AntiClastic", spanning the fields of antisense therapeutics to immunomodulating therapeutics. The team works closely with external partners to discover and develop AntiClastic RNA medicines. As a Senior Scientist / Principal Scientist – Translational Medicine, you will serve as the translational medicine leader for the Genetic Medicines team at Alloy Therapeutics. In this role, you will drive all aspects of translational medicine for our oligonucleotide drug discovery programs, including design of preclinical pharmacology and toxicology studies. You will bridge rodent and NHP preclinical sciences by integrating DMPK, PK/PD, and biomarker data to build translational results that support candidate selection and advancement. A central focus of this role is leading and expanding Alloy's preclinical study capabilities, from study design through data interpretation. This role requires strong project management capabilities and the ability to operate with a high degree of autonomy in a fast-paced, dynamic start-up environment. Experience in oligonucleotide therapeutics is strongly preferred.

Requirements

Ph.D. in Pharmaceutical Sciences, Biochemistry, Molecular Biology, or a related discipline, with 6+ years of experience in biotech/pharma in a translational or DMPK role; or M.S. with 8+ years of relevant industry experience.
Extensive hands-on experience designing and overseeing in vivo PK/PD studies in NHP is required.
Familiarity with quantitative translational modeling approaches (e.g., allometric scaling, PBPK, PK/PD) is a plus.
Proficiency in bioanalytical methods for oligonucleotide quantification (e.g., LC-MS/MS, hybridization-based assays).
Experience with PK/PD data analysis tools (e.g., Phoenix WinNonlin, GraphPad Prism).
Demonstrated project management skills, including the ability to manage multiple programs, external CROs, and cross-functional timelines simultaneously.
Excellent written and verbal communication skills; ability to distill complex translational data into clear, decision-enabling summaries for diverse audiences.
Proven ability to work independently and collaboratively in a fast-paced, start-up environment.

Nice To Haves

Deep expertise in translational medicine as applied to oligonucleotide therapeutics (ASOs, siRNA, or related modalities) is strongly preferred.
Familiarity with IND-enabling translational study design and regulatory expectations.
Prior experience managing or mentoring scientists in a research setting.

Responsibilities

Lead translational projects and workstreams, overseeing study timelines, managing CRO deliverables, and proactively communicating risks and updates to stakeholders.
Develop and lead translational PK/PD plans for oligonucleotide programs, integrating data across rodent and NHP species to support candidate selection and progression to clinical development.
Own end-to-end NHP study execution: design studies, oversee sample collection and bioanalysis, and interpret data in the context of program objectives.
Apply translational PK/PD modeling approaches to contextualize and compare PK, efficacy, and safety data across preclinical species.
Oversee in vivo DMPK studies across multiple preclinical species, including NHP, encompassing pharmacokinetics, pharmacodynamics, toxicokinetics, biodistribution, and target-based and off-target effects.
Lead toxicokinetic assessments, including exposure-response analysis and TK/PD evaluations, to contextualize safety findings across species.
Integrate DMPK and biomarker data into coherent translational narratives that inform compound advancement decisions.
Identify, develop, and qualify translational biomarkers (PK, PD, and safety) to support target engagement and proof-of-biology in NHP models.
Prepare and present high-quality translational summaries and data packages for internal program reviews and external partnerships.
Maintain comprehensive and accurate records using electronic lab notebooks (e.g., Benchling), ensuring meticulous documentation and data integrity.
Mentor and provide scientific guidance to junior team members, fostering a culture of scientific rigor and innovation.

Benefits

Competitive base and equity compensation commensurate with level of experience and independence
401(k) company match
Generous personal and family medical, dental and vision benefits with 100% of premiums and deductibles covered
Company-paid disability (STD, LTD) and life insurance
Paid parental leave
Family planning support up to $45,000 (e.g., IVF/PGT, adoption, surrogacy, egg retrieval)
Unlimited PTO (paid time off) and flexible schedules
Annual stipend for continuing education with commitment to your career through individualized professional development plan
Wellness and Extensive Employee Assistance Program (EAP) including resources for mental wellness

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