Senior Principal Scientist, Discovery Chemistry

Bristol Myers Squibb • San Diego, CA

22h • Onsite

About The Position

Accomplished medicinal chemist aiming to lead and contribute to the BMS portfolio as an integral member of the Global Discovery Chemistry (GDC) organization, based in San Diego We are seeking a talented and highly motivated individual with a strong background in medicinal chemistry to join our Discovery and Development Sciences (D&DS) team in San Diego. The successful candidate will contribute and lead a team of scientists that engage in rational design of new agents for the potential treatment of diverse oncology indications. The individual will apply modern drug design principles to solve medicinal chemistry problems relevant to the Protein Homeostasis Thematic Research Center project portfolio. Furthermore, you will also collaborate with a broad group of scientists within the BMS Discovery and Development Sciences group to advance the projects from inception to IND.

Requirements

• Ph.D. in synthetic organic chemistry with 6+ years pharmaceutical medicinal chemistry industrial experience (8+ years preferred) or M.S. in synthetic organic chemistry with 8+ years pharmaceutical medicinal chemistry industrial experience (10+ years preferred) or B.S. in synthetic organic chemistry with 10+ years pharmaceutical medicinal chemistry industrial experience (12+ years preferred)
• Demonstrated ability to contribute and advance drug discovery programs with strong proficiency in fundamental aspects of drug discovery are required
• Track record of innovation and impact on programs documented through co-inventorship on issued patents and authorship of publications in peer-reviewed journals is necessary (may include both successful advances and data-driven terminations)
• Strong working knowledge of protein-ligand interactions, ADME, conformational and structural analysis, experienced in partnering closely with computational chemists through appropriate use of AI/ML and computational predictive tools and models as well as visualization applications.
• High level of creativity and productivity with strong synthetic productivity, problem solving skills, synthetic methods, and reaction mechanisms are required
• Ability to champion chemistry efforts into new directions to achieve project milestones
• Strong skills in gathering, documenting, and analyzing information from competitive sources such as patents and meetings and using this information to guide program strategy
• Proven leadership capability in cross-functional teams, either as project team leader or co-leader
• Proven track record of mentoring PhD and/or MSc/BSc-level scientists to high levels of productivity, whilst improving the skills and knowledge of direct reports through mentorship and focused development activities
• Excellent communication skills and able to present the rationale, key data, issues and accomplishments of the chemistry efforts to other members of the R&ED organization
• Fit with BMS Culture and Values
• Diversity and inclusion
• Strong team orientation; highly collaborative, both within internal San Diego group and across the broader GDC and D&DS organization.
• Solutions and results-oriented focus
• Hands-on approach; resourceful and open to diverse points of view

Nice To Haves

• Previous experience supporting and advancing target protein degradation and/or antibody-drug conjugate programs is preferred.

Benefits

• Health Coverage: Medical, pharmacy, dental, and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day. All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree