Principal Scientist / Senior Scientist, Analytical Chemistry (Biopolymers)
About The Position
BreezeBio is an early-stage biotech company building a next-generation delivery platform for genetic medicines. Our team integrates chemistry, payload design, formulation, and preclinical science to translate platform innovation into a pipeline of transformative therapies. We operate in a fast-paced environment where creative problem-solving and high-impact data drive decisions. We are seeking a Principal/Senior Scientist with deep expertise in polymer-based nanoparticle characterization to lead our analytical efforts from the bench. This is a hands-on role focused on developing the methods that define our platform. You will serve as the Subject Matter Expert (SME) for biopolymer characterization, driving method development, early-stage QC, and the analytical documentation required to successfully navigate IND-enabling studies. The ideal candidate thrives at the interface of discovery and development, ensuring that our innovative chemistry is backed by robust, reproducible analytical methods.
Requirements
- Ph.D. in Chemistry, Polymer Science, or a related field with 5â8+ years of industry experience (MS/BS with equivalent proven experience will be considered).
- Direct experience in early-stage development and a clear understanding of the requirements to move a program through IND filing.
- Expert-level proficiency in GPC/SEC with MALS detection is essential.
- Strong hands-on experience with HPLC and various detector modalities (UV-Vis, RI, ELSD).
- Experience with nanoparticle characterization (DLS, NTA, Zeta potential) and biopolymer chemistry.
- Experience in authoring qualification reports and performing rigorous data review.
- Ability to work primarily onsite in a fast-paced laboratory environment.
- Strong "ownership" mindsetâwilling to do the bench work while thinking strategically about the long-term lifecycle of the product.
- Excellent communication skills for collaborating across chemistry and formulation teams.
Responsibilities
- Lead the development and optimization of analytical methods for polymer-based nanoparticles, with a heavy emphasis on GPC/SEC-MALS and HPLC.
- Characterize polymer molecular weight distributions, architecture, and purity to support formulation and process development.
- Translate early-stage "research" methods into robust, qualified procedures suitable for formal development.
- Establish and execute QC protocols for incoming polymers and nanoparticle batches; perform routine testing to support internal programs.
- Author and review technical documents, including method qualification reports, SOPs, and batch records.
- Ensure all analytical activities meet phase-appropriate quality standards (moving toward cGMP/ICH alignment).
- Drive the analytical strategy for IND submissions, ensuring data integrity and method suitability for regulatory filings.
- Support CMC teams in defining specifications and control strategies for polymer-based delivery systems.
- Provide technical oversight for external CDMOs as methods are transferred for later-stage manufacturing.
Benefits
- Opportunity to be a foundational member of a high-growth biotech.
- Work on cutting-edge gene therapy delivery technologies where your data directly influences the platform.
- Collaborative, science-driven culture with competitive compensation, equity, and benefits.
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
Education Level
Ph.D. or professional degree
