Senior Scientist/Principal Scientist, Protein Sciences: Analytical & Biophysical Characterizations

Soleil Labs, LLC•South San Francisco, CA

1d•$140,000 - $210,000•Onsite

About The Position

Soleil is seeking an expert, hands-on scientist to lead our analytical and biophysical characterization efforts within the Protein Sciences group of the Technology team. In this role, you will design, develop, validate, and execute comprehensive developability assessments and analytical characterizations for our biologics portfolio (antibodies, multi-specifics, fusion proteins). You will be the go-to expert for complex analytical challenges, drive technical strategy across programs, and work collaboratively with research and development teams to generate critical data that inform candidate selection and progression. This is a highly technical, hands-on position where you will spend time at the bench while contributing strategic leadership on analytical and developability matters. This is a full-time, lab-based position with 20% hands-on technical execution.

Requirements

Ph.D. or equivalent in a related discipline (e.g. molecular biology, biochemistry, biophysics, analytical chemistry) with 5+ years' experience in protein and antibody characterization and developability in an industry setting, preferably startup or biotechnology companies
Expert in biophysical and analytical techniques including but not limited to HPLC, CE, SPR, DSF, DSC, SEC-MALS, LC-MS, and immunogenicity assays
Solid, hands-on understanding of protein analytical principles, methodologies, and PTMs characterization
Extensive, hands-on experience in developability studies for antibody therapeutics, including monoclonal, bispecific, and multi-specific antibodies, fusion proteins, and antibody-drug conjugates
Deep understanding of attributes of protein therapeutic drug candidates and biologics drug discovery process (hit-to-lead, lead optimization, candidate selection)
Demonstrated excellence at troubleshooting complex analytical and characterization challenges and explaining technical approaches to cross-functional audiences
Strong attention to detail in experimental design and execution; capable of running multiple experiments in parallel without compromising quality or rigor
Excellent oral presentation and written communication skills, with ability to synthesize complex data into clear summaries for technical and non-technical stakeholders
Strong collaborative and mentoring skills; able to work effectively across functional groups and help junior scientists develop
Flexible, adaptable, and quick to learn new techniques and technologies; thrives in fast-paced, dynamic environments
Familiarity with CMC development process; prior experience with IND filing is highly desired

Nice To Haves

Experience with protein purification, membrane proteins, and/or multi-specific antibody formats is highly desired
Prior experience with managing direct report(s) is preferred

Responsibilities

Design, develop, validate, and execute analytical and biophysical methods (with emphasis on LC-MS, chromatography, thermal/structural assays, and immunogenicity assessments) for diverse protein and antibody formats
Establish robust, fit-for-purpose assays that characterize therapeutic biologics throughout the preclinical pipeline
Execute experiments with precision, conduct detailed observations, analyze and interpret data rigorously, and deliver results in a timely, concise manner to program teams
Prepare and lead comprehensive developability assessments packages for biologic candidates, evaluating stability, solubility, aggregation, post-translational modifications, manufacturability, immunogenicity potential, and key risk factors
Serve as technical lead for due diligence and business development contexts: evaluate external analytical data, review technical packages, identify risk, and advise senior decision-makers on analytical feasibility and candidacy
Define analytical strategy across the portfolio in collaboration with research, CMC, and program teams; ensure alignment with formulation and process development
Serve as SME for complex analytical and characterization challenges; provide expert guidance to cross-functional teams on technical issues and method refinements
Evaluate emerging analytical technologies for feasibility and performance; guide adoption to enhance throughput, sensitivity, and risk mitigation
Mentor junior scientists and collaborate with peers on scientific approaches and best practices
Manage experienced scientist as direct report
Play a key analytical role in drug candidate selection decisions across the portfolio; advise senior leadership on analytical feasibility and developability risk
Manage CROs and external collaborations for method development, validation, tech transfer, and analytical support; ensure quality, timelines, and cost efficiency
Prepare precise technical summaries, protocols, analytical packages, and maintain rigorous documentation standards suitable for regulatory submissions and internal reporting
Contribute to program team discussions as a functional technical lead, effectively communicate across line-functions