Senior Scientist, Analytical Sciences (Contract)

ORIC Pharmaceuticals•South San Francisco, CA

2d•Onsite

About The Position

ORIC Pharmaceuticals is a clinical stage biopharmaceutical company dedicated to improving patients’ lives by Overcoming Resistance In Cancer. ORIC’s clinical stage product candidates include (1) rinzimetostat (ORIC-944), an allosteric inhibitor of the polycomb repressive complex 2 (PRC2) via the EED subunit, being developed for prostate cancer, and (2) enozertinib, a brain penetrant inhibitor that selectively targets EGFR exon 20, HER2 exon 20 and EGFR atypical mutations, being developed across multiple genetically defined cancers. Beyond these two product candidates, ORIC® is also developing multiple precision medicines targeting other hallmark cancer resistance mechanisms. ORIC has offices in South San Francisco and San Diego, California. We are seeking an experienced Senior Scientist with a proven record of sustained laboratory achievement and innovation. The selected candidate will provide lab support across various projects and teams; contribute to our shared mission of bringing new therapies to cancer patients.

Requirements

Requires a M.Sc. degree in chemistry with >8 years of relevant research experience, or a Ph.D. degree with a minimum of 3 years of hands-on pharmaceutical/biotech industry experience, or equivalent, in the field of new drug discovery and development.
Hands-on experience with laboratory techniques, including chromatography (e.g., HPLC, GC, LC/MS), spectroscopy (e.g., UV-Vis, FTIR), titration methods (e.g., Karl Fischer, acid-base), dissolution testing, particle size analysis (by laser diffraction), microscopy, and other compendial methods.
Experience using laboratory software to collect, analyze, and report data. This might include instrument control software (Openlab, Empower, etc.) or data analysis programs (Excel, etc.).
A strong attention to detail and demonstrated prior experience working in GLP, cGMP environment.
Demonstrated ability to take initiative, ownership, problem identification, problem solving and strategic input.
Excellent communication and organization skills; ability to work independently and efficiently collaborate in a fast-paced, integrated, multidisciplinary team environment.
Exceptional problem-solving skills, scientific curiosity, critical thinking, and ability to quickly adapt and shift focus as needed.

Nice To Haves

Experience working in late-stage development or commercialization environments is preferred.
Hands-on in-plant experience within a manufacturing or production setting is highly preferred.

Responsibilities

Independently lead analytical development and product characterization activities for one or more molecules in CMC development.
Able to independently develop and optimize analytical methods to support early and late-stage development.
Expected to solve challenging problems by application of one or more (traditional or emerging) analytical techniques.
Independently design experiments, perform sample analysis using general laboratory techniques, such as weighing, pipetting, and operating laboratory instruments (HPLC, LC-MS, GC, UV-Vis, KF, DSC, TGA, XRPD, etc.).
Execute analysis with a solid understanding of the test procedures, underlying science, and proper instrument operation, ensuring accurate and reliable results.
Utilize available software to control instruments, collect data, process and calculate results, and prepare comprehensive reports.
Maintain precise and comprehensive records of all analyses in a lab notebook in real time, ensuring compliance with company standards and promoting traceability and consistency in data reporting.
Prepare presentation materials and clearly communicate research results to the manager, and present at internal meetings.
Author/review technical reports, technical packages, and relevant sections in health authority filings.