Senior Scientist or Scientist - Drug Metabolism and Pharmacokinetics (DMPK)
About The Position
The Senior Scientist or Scientist conducts laboratory-based studies under the general guidance of the Director and independently designs and executes experiments to support drug discovery and development in their area of expertise. The role analyzes and interprets data, refines experimental approaches, and contributes to communicating and reporting research findings. This is a hands-on, bench-focused laboratory position on an academically oriented team primarily supporting small-molecule drug discovery and development. The scientist directly performs bioanalytical, in vitro DMPK, and in vivo pharmacokinetic studies rather than managing or outsourcing the work. The position supports a DMPK-style workflow in an academic, nonprofit environment.
Requirements
- Bachelor's degree in Chemistry, Biology, Pharmacology, Pharmaceutical Sciences, or a related discipline.
- Demonstrated experience with LC-MS/MS bioanalysis for small molecules.
- Practical laboratory experience running in vitro DMPK/ADME assays, including protein binding, microsomes, hepatocytes, and monolayers.
- Direct hands-on experience executing in vivo PK studies, including dosing, sampling, and tissue collection.
- Working knowledge of preclinical formulation techniques involving solutions and suspensions.
- Strong attention to detail and organizational skills, with the ability to plan and work independently while collaborating effectively.
- Scientist: 8 years of relevant work experience; 6 years with a Master's degree; or 3 years with a PhD.
- Senior Scientist: 10 years of relevant work experience; 8 years with a Master's degree; or 5 years with a PhD.
Nice To Haves
- Experience with SCIEX instrumentation for LC-MS/MS bioanalysis.
Responsibilities
- Perform quantitative LC-MS/MS bioanalysis of small and/or large molecules in biological matrices, including plasma and tissues, from in vitro and in vivo studies supporting PK/PD, ADME, and efficacy evaluations.
- Execute in vitro DMPK assays, including plasma protein binding, microsomal stability incubations, hepatocyte metabolism studies, and permeability assessments in cell monolayers.
- Conduct in vivo PK studies, including dosing by standard routes, terminal and non-terminal blood sampling, and organ and tissue collection.
- Develop and/or prepare preclinical formulations by dissolving or suspending test agents for in vivo dosing.
- Analyze data, maintain accurate records in LIMS, laboratory notebooks, and reports, and communicate results to the Director and project team.
- Perform other related duties as assigned to meet department and institutional goals.
- Maintain regular and predictable attendance.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
