Senior /Principal Scientist- (Multiple Sclerosis)

Roche • South San Francisco, CA

5d • $120,700 - $262,900

About The Position

Genentech’s Translational Medicine department (TM-OMNI) conducts translational research to inform clinical development across Ophthalmology, Metabolism, Neuroscience, Immunology, and Infectious Diseases. Its work includes clinical biomarker discovery and development, personalized healthcare strategies, and research into molecular and cellular pathways that may inform new targets and biomarkers.

The department is seeking a Senior Scientist or Principal Scientist to lead biomarker, drug-development, and/or translational research efforts in multiple sclerosis (MS). The role focuses on identifying approaches to treat MS, designing and interpreting biomarker studies, and using biomarkers to accelerate clinical development. The group works with human clinical samples and molecular and cellular phenotyping to study disease heterogeneity and therapeutic effects, supporting understanding of disease pathogenesis and drug discovery and development. Lab Group Heads provide scientific leadership for projects addressing unmet needs and advancing clinical trials through biomarker discovery or development.

The successful candidate will contribute scientific leadership and work independently to develop hypotheses, guide laboratory scientists, and develop computational strategies for analysis and interpretation. They will collaborate across internal functions and with external partners, and communicate research through presentations, clinical documentation, regulatory filings, and scientific publications. Collaboration across time zones, including with Genentech’s Swiss site, is required. Relocation benefits are not available.

Requirements

• PhD in Neuroscience, Immunology, or a related field.
• At least 3 years of postdoctoral experience in basic or translational research in academia and/or industry.
• High level of independence and ability to develop hypotheses, direct laboratory scientists, and develop computational strategies for analysis and interpretation.
• Strong writing and communication skills, evidenced by publications, meeting abstracts, and/or drug-development reports.
• Ability to collaborate across time zones, including with the Swiss site.
• Ability to function as part of a cross-functional team, such as a research or clinical-trial project team.
• Experience or familiarity with molecular/immunological techniques and analytical methods, including immunoassay, qPCR, complex in vitro modeling systems, functional genomics, genomic sequencing, scRNA-seq, TCR-seq, CITE-seq, spatial transcriptomics, and/or computational methods and analytics.

Nice To Haves

• Prior experience in multiple sclerosis.
• Knowledge of R or Python.

Responsibilities

• Identify new targets and biomarkers in support of multiple sclerosis drug-development projects.
• Lead efforts supporting clinical trials, data generation and analysis in internal studies, and/or external academic collaborations focused on MS pathogenesis.
• Integrate biomarkers into clinical trials and contribute to target identification or validation.
• Develop hypotheses, direct laboratory scientists, and develop computational strategies to support analysis and interpretation.
• Work in partnership with Research, the Bioanalytical Assay Department, Diagnostics, Clinical, Biostatistics, Computational Science, Regulatory, and external partners.
• Present findings to cross-functional teams, internal review committees, and external conferences.
• Write biomarker sections of clinical protocols, reports, regulatory filings, and scientific publications.
• Mentor others, including direct reports, students, or interns.

Benefits

• A discretionary annual bonus may be available based on individual and company performance.
• Benefits are referenced through a link in the posting, but specific benefits are not listed.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree