Senior /Principal Scientist- (Multiple Sclerosis)

Genentech • Daly City, CA

4d • $120,700 - $262,900

About The Position

Genentech's Translational Medicine department (TM-OMNI) is seeking a Senior Scientist or Principal Lab Group Head to advance biomarker and drug development and translational research in multiple sclerosis (MS). The department conducts translational research across Ophthalmology, Metabolism, Neuroscience, Immunology, and Infectious Diseases, including clinical biomarker discovery and development, personalized healthcare strategies, and research into molecular and cellular pathways that may inform new targets and biomarkers.

The role focuses on identifying new targets and biomarkers for MS drug development, supporting clinical trials, generating and analyzing data in internal studies, and leading external academic collaborations to understand MS pathogenesis. The position applies human clinical samples and molecular and cellular phenotyping to investigate disease heterogeneity and therapeutic disease modification. Lab Group Heads provide scientific leadership for projects addressing unmet disease needs and advancing clinical trial development. The role works closely with internal functions and external partners and communicates findings through presentations and scientific and regulatory writing.

Requirements

• PhD in Neuroscience, Immunology, or a related field.
• At least 3 years of post-doctoral experience in basic or translational research in an academic and/or industry setting.
• High level of independence and ability to develop hypotheses, direct lab scientists, and develop computational strategies for analysis and interpretation.
• Record of mentorship, such as mentoring direct reports, students, or interns.
• Strong writing and communication skills, evidenced by publications, meeting abstracts, and/or drug development reports.
• Ability to function as part of a cross-functional team, such as a research or clinical trial project team.
• Willingness to collaborate across time zones, including with the Swiss site.

Nice To Haves

• Prior experience in multiple sclerosis.
• Familiarity with molecular and immunological techniques and analytical methods, including immunoassay, qPCR, complex in vitro modeling systems, functional genomics, genomic sequencing, scRNA-seq, TCR-seq, CITE-seq, spatial transcriptomics, and/or computational methods and analytics such as R or Python.
• Experience integrating biomarkers into clinical trials and/or with target identification or validation.

Responsibilities

• Identify new targets and biomarkers in support of multiple sclerosis drug development projects.
• Support clinical trials and lead data generation and analyses within internal studies.
• Lead external academic collaborations related to understanding multiple sclerosis disease pathogenesis.
• Integrate biomarkers into clinical trials and contribute to target identification or validation.
• Develop hypotheses, direct lab scientists, and develop computational strategies to support analysis and interpretation.
• Partner across Research, Bioanalytical Assay Department, Diagnostics, Clinical, Biostatistics, Computational Science, Regulatory, and external organizations.
• Present findings to cross-functional teams, internal review committees, and external conferences.
• Write biomarker sections of clinical protocols, reports, regulatory filings, and scientific publications.
• Collaborate across time zones, including with the Swiss site.

Benefits

• A discretionary annual bonus may be available based on individual and Company performance.
• Benefits are referenced through a link in the posting; specific benefits are not listed.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree