Senior Scientist - Oligo Bioinformatics

Merck•Billerica, MA

2d•Onsite

About The Position

EMD Serono in Billerica, MA is seeking a Senior Scientist – Oligo Bioinformatics to add to their Oligonucleotide Therapeutics Group (DDTech). This role involves utilizing Bioinformatics platforms to design, evaluate and optimize siRNA sequences for targeted gene silencing, analyzing gene expression data to identify suitable targets for siRNA/ASO development, and working closely with chemists and biologists to integrate bioinformatics approaches into experimental workflows. The position also includes performing transcriptome-wide off-target prediction and annotation, and developing pipelines that determine mapping coordinates and homology of oligonucleotides to genomes and transcriptomes.

Requirements

PhD in Chemistry, Chemical Engineering or other Science or Engineering discipline with 3+ years of direct experience
Oligonucleotide field
Proficient in Bioinformatics tools and software (e.g. BLAST, RNA fold, siRNA design tools)
Ability to analyze large genomic and transcriptomic datasets including RNA seq, Single cell RNA seq, splice isoforms and variant database
Highly collaborative with strong problem-solving ability

Nice To Haves

Strong scientific curiosity and innovation mindset

Responsibilities

Utilize Bioinformatics platforms to design, evaluate and optimize siRNA sequences for targeted gene silencing
Analyze gene expression data to identify suitable targets for siRNA/ASO development
Work closely with chemists and biologists to integrate bioinformatics approaches into experimental workflow
Perform transcriptome wide off-target prediction and annotation
Develop pipelines that determine mapping coordinates and homology of oligonucleotides to genomes and transcriptomes