Senior Scientist, Multispecific Antibody Engineering (Oncology)

AbbVie•Worcester, MA

About The Position

Discovery Biotherapeutics at AbbVie is seeking a highly skilled and self-motivated scientist to join a dynamic team supporting design, engineering, and manufacturing of multispecifics. This position will impact projects through engineering, production, and characterization of multispecific biopharmaceutical products. The ideal candidate should have extensive experience with biologics and multispecifics production platforms, analytical characterization, and a proven track record implementing multispecific engineering and production strategies to advance early- and late-stage discovery programs. The applicant should be an enthusiastic, creative scientist who will make tangible contributions to the continuous improvement and innovation within the organization.

Requirements

PhD, MS, or BS degree in Biochemistry, Biochemical engineering or related disciplines with typically 0-5 (PhD), 8-11 (MS), or 10-13 (BS) years of experience, ideally in multispecifics biologics engineering
Extensive experience with protein, biologics, fragments, and multi-specifics design, expression and purification
Experience with purification and automation instruments e.g. Akta, Kingfisher, Hamilton
Sound scientific understanding of current state of protein expression/separation/analytical technologies and ability to explore and develop new approaches for innovative purification
Experience with CRO coordination
Experience with in vitro analytical techniques for protein characterization (e.g. SEC, MS, DSF); experience with developability screening for multispecifics preferred
Strong molecular biology skills (e.g. molecular cloning) and experience with sequence analysis tools (Vector NTI, Geneious, Genedata)
Knowledge of biologic pipeline progression from exploratory through candidate nomination with program management experience preferred
Excellent organizational skills and the ability to manage multiple projects simultaneously and adapt to rapid change in priorities
Candidate must be a goal-oriented team player with excellent verbal and written communication skills, ability to operate in a fast-paced multi-disciplinary environment, and strong can-do attitude
Builds strong relationships with peers and cross functionally with partners outside of the team to enable high performance
Learns fast, grasps the “essence” and can change the course quickly where indicated
Raises the bar and is never satisfied with the status quo
Creates a learning environment, open to suggestions and experimentation for improvement
Embraces the ideas of others, nurtures innovation and manages innovation to reality

Nice To Haves

Design experience of multispefics for ADC is preferred
Recognized in the scientific community through a sustained record of peer-reviewed publications and patents preferred

Responsibilities

Responsible for design, engineering and production of multispecific biologics to support oncology
Evaluate and integrate state-of-the-art technology to improve therapeutic production platforms, and demonstrate creative “out-of-the-box” thinking to solve difficult problems
Serve as a Multispecifics Engineering representative for cross-functional teams, and contribute scientific insights into multiple projects across various therapeutic areas; recognized expert in multispecifics design and production
Serve as the Biologics lead on projects to coordinate activities and transitions from hit generation through candidate nomination
Identify and solve technical problems independently, conceive and implement innovative process research ideas
Ensure consistency and quality of technical reports
Provide project update, analysis and advice to cross-functional teams and senior management
Present original work internally across departments and at internal and external scientific conferences; may author or co-author peer-reviewed scientific papers or patents