Antibody Discovery Associate Scientist/Scientist

Oxford BioTherapeutics•San Jose, CA

10h

About The Position

As an Antibody Discovery Associate Scientist/Scientist, you will play a key role in discovering both tool and therapeutic antibodies using state‑of‑the‑art in vivo and in vitro approaches. You’ll collaborate closely with cross‑functional teams, contribute to experimental design, and help drive projects forward in a fast‑paced, highly innovative environment. This role is an excellent fit for someone who is proactive, detail‑oriented, scientifically curious, and excited to work on cutting‑edge antibody discovery pipelines.

Requirements

BS/MS/PhD in Immunology, Molecular Biology, Biochemistry, Cell Biology, or a related field.
BS/MS: 3–5 years’ hands‑on experience in antibody discovery (industry preferred)
PhD: 1–2 years’ experience
Experience with flow cytometry/FACS for antigen‑specific B‑cell sorting (SONY sorter experience a plus)
Proficiency in single‑cell RT‑PCR, PCR, cloning, expression, and sequence analysis
Experience with NGS workflows — library prep, indexing, QC — and repertoire analysis tools (e.g., MiXCR, IgBLAST, PipeBio)
Familiarity with SPR/BLI for kinetics and epitope binning
Competence in data analysis software such as FlowJo, Geneious Prime, Biacore/Octet, and GraphPad Prism
Strong written and verbal communication skills

Nice To Haves

Experience with CRISPR gene editing
Understanding of antibody developability assessment

Responsibilities

Single B‑cell discovery: Plan and execute multiparameter flow cytometry for antigen‑specific B‑cell sorting; recover paired VH/VL sequences using single‑cell RT‑PCR; perform molecular cloning and antibody expression for rapid screening.
Molecular recovery & sequencing: Develop and perform workflows for RT‑PCR/PCR, barcoding, and amplicon QC; prepare NGS libraries and support sequencing for deep repertoire capture.
Repertoire mining & clonal analysis: Analyse BCR repertoires (VDJ assignment, CDR annotation), perform clonal clustering and lineage inference, and identify promising antibodies using developability/sequence‑liability assessments.
High‑throughput screening (HTS): Run ELISA, Octet, and cell-based assays to assess specificity, affinity, and expression levels.
Antibody characterisation: Perform kinetics and epitope binning (BLI/SPR), assess cross-reactivity and affinity maturation, and contribute to mechanism-of-action assays.
Data analysis & reporting: Own QC, analysis, and visualisation of experimental data; prepare clear written summaries and present findings to internal and external partners.
Operational excellence: Maintain high‑quality scientific records, support workflow optimisation, and uphold lab safety and data integrity.

Benefits

Medical, dental, and vision insurance for employees and dependents
Flexible Spending Account (FSA)
Short‑Term Disability (STD), Long‑Term Disability (LTD), Basic Life & AD&D, and Supplemental Life insurance
401(k) plan
120 hours of Paid Time Off + 5 sick days per year
11 public holidays
Annual bonus program
Employee referral bonus program
New hire stock options

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