Senior Scientist Medium Scale Oligo Synthesis

EMD Serono Research & Development Institute • Billerica, MA

2d

About The Position

This role is for a Senior Scientist focused on Medium Scale Oligo Synthesis within EMD Serono's Healthcare division. The purpose of the Healthcare division is to help create, improve, and prolong lives by developing medicines, intelligent devices, and innovative technologies in therapeutic areas such as Oncology, Neurology, and Fertility. The teams work collaboratively across continents with passion and curiosity to assist patients at every stage of life. Joining the Healthcare team means becoming part of a diverse, inclusive, and flexible working culture that offers significant opportunities for personal development and global career advancement. This role requires external applicants to be eligible to work in the US as sponsorship for work authorization is not provided.

Requirements

• PhD in Chemistry, science, or engineering.
• 5+ years of direct experience in oligonucleotide chemistry.

Nice To Haves

• Strong knowledge of Oligonucleotide Synthesis, Deprotection, and Purification techniques.
• Knowledge and background in bioconjugation chemistry including antibody-drug conjugates and related linkers.
• Experience in conjugation/bioconjugation chemistry.
• Solid-phase synthesis techniques with oligonucleotides or peptides.
• Expertise in chromatography purification techniques and troubleshooting.
• Strong laboratory skills and experience with analytical instrumentation such as NMR, HPLC, LC-MS, etc.
• Ability to analyze, interpret, and clearly present data.

Responsibilities

• Design, synthesis, purification, and analysis of ASO, siRNA, and/or their conjugates to small molecules, peptides, dyes, and antibodies.
• Operate Mermade 12 and Akta Synth synthesizers using Phosphoramidite chemistry.
• Perform solid-phase synthesis of oligonucleotides at medium scales (20 mg - 1.0 g).
• Conduct large-scale purification and ultrafiltration of oligonucleotides by anion-exchange and reverse-phase HPLC systems.
• Demonstrate a deep understanding of oligonucleotide and precursor synthesis, purification, and familiarity with analytical methods in oligonucleotide drug development.
• Work effectively as part of a team with an excellent work ethic.
• Present findings in team meetings.
• Maintain a well-documented laboratory notebook and follow safe laboratory practices.
• Multi-task across several projects and manage time effectively to achieve results.

Benefits

• health insurance
• paid time off (PTO)
• retirement contributions
• other perquisites

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree