Senior Scientist, in vivo Pharmacology

Stoke Therapeutics • Bedford, MA

8h • Onsite

About The Position

The Senior Scientist will work collaboratively across the Research organization to support preclinical discovery efforts to understand the pharmacokinetics, pharmacodynamics, and efficacy of novel compounds in disease models. This position requires a scientist with deep expertise designing and developing robust assays to investigate preclinical pharmacokinetic, pharmacological, and functional biomarkers in tissue samples. This position will report into the Executive Director of in vivo pharmacology.

Requirements

• Bachelor’s degree with 16+ years of experience, or Master’s degree with 10+ years of post-graduate experience, or Ph.D. with 6+ (industry experience is required). Degrees in Pharmacology, Neuroscience or relevant disciplines preferred.
• Deep experience developing and optimizing assays (i.e MSD, ELISA, H-ECL, LCMS, qPCR) in complex matrices, IHC skills a plus.
• Experience working in drug discovery with an emphasis on neurology indications, experience working with oligonucleotides preferred.
• Designing and managing experiments at contract research organizations.
• Excellent verbal and written communication skills.
• Excellent planning, organization and time management skills including the ability to support and prioritize multiple projects.

Nice To Haves

• Experience with PK/PD modeling a plus.

Responsibilities

• Develop and optimize preclinical PK,PD, and biomarker assays to support preclinical research efforts and bridge into early development activities.
• Use a high level of scientific judgment and creative thinking to adapt and/or create standard methods by applying breadth of knowledge and prior work experience.
• Work collaboratively within and across functions to support programs from early discovery through preclinical proof of concept and candidate selection to advance the company pipeline.
• Maintain excellent and timely recordkeeping while adhering to aggressive timelines
• Author study reports that may be used for regulatory filings and scientific manuscripts.

Benefits

• medical, dental and vision insurance
• life, long- and short-term disability insurance
• paid parental leave
• a 401K plan with company match
• unlimited vacation time
• tuition assistance
• participation in our Employee Stock Purchase Program (ESPP)

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level