Senior Scientist – In Vivo Pharmacology, Oncology R&D

AstraZeneca • Gaithersburg, MD

1d • Onsite

About The Position

Are you ready to make a difference in the world of Oncology? We are seeking a pharmacology Senior Scientist within the Oncology Targeted Delivery (OTD) group to serve as an in vivo lead supporting both preclinical and clinical ADC (antibody drug conjugate) programs. This role will work with colleagues to generate robust datasets directly impacting oncology ADC drug discovery and pipeline development.

Requirements

• PhD with 2+ years or a BS/MS with 5+ years of relevant research experience in biology, pharmacology, or a related scientific discipline is required.
• Significant hands-on experience developing and working with complex in vivo models, such as syngeneic, cell line derived xenograft, patient derived xenograft (PDX), and orthotopic/humanized mouse models.
• Excellent at executing in vivo pharmacology studies in mouse tumor models, including dose-finding tolerability studies, PK/PD and efficacy studies.
• Excellent at various routes of dosing administration, including intravenous (IV), subcutaneous (SC), intraperitoneal (IP), and oral gavage (PO)
• Experience with a range of in vitro skills, e.g. cell culture (adherent cells and suspension cells), molecular biology, immunoblotting, flow cytometry and ELISA.
• Ability to work independently, critically analyze and report data, and interpret experimental findings within the broader landscape of drug discovery.
• Highly developed problem solving and risk management skills, and attention to detail.
• Strong interpersonal, collaborative and team building skills.
• Experience in preparing and communicating project data packages for internal milestone transitions and IND filings which exemplify a clear communication style.
• Ability to act as an external ambassador and to influence external organizations to enhance the image and reputation of AstraZeneca.

Nice To Haves

• In-depth knowledge of ADCs and/or oncology disease area biology.

Responsibilities

• Working within the Early Oncology In Vivo Pharmacology Team, you will design, run and analyze in vivo experiments to assess the function of our candidate oncology drugs and dissect the mechanism of action of novel cancer therapeutics.
• You will be expected to collaborate with cross-functional teams including representatives from biosciences, bioanalysis, pharmacokinetics, translational medicine, clinical, and safety to help understand the translatability of in vivo research to the clinic.
• You will work collaboratively with project leaders to ensure the timely generation, and dissemination of critical program data, and contribute to scientific publication goals.
• As a highly organized, self-motivated individual with a strong background in laboratory science you will stay up to date with relevant technical and intellectual scientific expertise in tumor biology, pharmacology and cancer modeling and have a genuine passion for this field of research.

Benefits

• Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree