Senior Scientist, in vivo Pharmacology, Genetically Engineered Models – Comparative Medicine
About The Position
We are seeking a highly motivated scientist to lead animal model creation efforts in a large-scale animal facility, working at the forefront of genome engineering and translational research alongside cross-functional teams and subject matter experts. This is an exciting opportunity to shape innovative in vivo models and make a direct impact on drug discovery and development at Biomedical Research-Novartis. The Global Genetically Engineered Models (GEMs) Team within Comparative Medicine (CM) is a key driver of innovation in animal science, preclinical care, and research model development, enabling research programs across Novartis worldwide. As a central partner in in vivo research, the team brings deep scientific expertise and collaborative leadership to the design, coordination, and execution of impactful preclinical activities. The Senior Scientist role is a highly technical and strategic opportunity to advance drug discovery and development across diseases with significant unmet medical need. This position offers the chance to deliver high-quality in vivo research support within a multidisciplinary environment while helping shape innovative model-based solutions that accelerate scientific progress.
Requirements
- Ph.D. in a natural or life science discipline, preferably molecular biology, genetics, or developmental biology, with 2+ of relevant hands-on experience working in a matrixed environment.
- Demonstrated expertise in genetically engineered animal model generation, including proficiency in PCR and next-generation sequencing for genetic characterization.
- Strong attention to detail and working knowledge of animal use protocols, welfare compliance requirements, and regulatory standards, with experience documenting studies in paper and electronic laboratory records.
Nice To Haves
- MS level candidates with 8+ years of directly related experience, preferably in industry.
- Proven ability to lead and influence programs or platform initiatives within a highly collaborative, matrixed environment.
- Working knowledge of advanced mouse model characterization approaches, including transcriptomics, proteomics, and metabolomics, to support deeper biological insight and translational relevance.
- Experience managing one to two direct reports, with the ability to support talent development and foster a strong team culture.
Responsibilities
- Drive the design and generation of genetically engineered mouse models using advanced CRISPR-based genome engineering approaches.
- Help advance the platform by developing and implementing innovative technologies and approaches for animal genome engineering.
- Lead the genetic and molecular characterization of engineered models to ensure scientific rigor and translational relevance.
- Ensure full compliance with all institutional and regulatory protocols, policies, and guidelines governing animal research.
- Stay at the forefront of the field by evaluating emerging technologies and applying new insights to strengthen in vivo disease modeling.
- Collaborate closely with the global GEMs team and external partners to expand model generation capabilities and deliver against program priorities.
Benefits
- health, life and disability benefits
- a 401(k) with company contribution and match
- a variety of other benefits
- a generous time off package including vacation, personal days, holidays and other leaves
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
