Senior Scientist, Immune-Aging

AstraZeneca • Waltham, MA

9d • Onsite

About The Position

AstraZeneca is seeking a Senior Scientist to join our growing T-cell Aging Unit and lead research focused on restoring immune function in aged populations. This role will pioneer research at the intersection of aging biology and immunology, translating findings into therapeutic interventions. The position primarily focuses on in vitro modeling and target validation. The successful candidate will also provide translational support by collaborating with external CROs and/or our in vivo pharmacology team to design in vivo studies and process animal tissues ex vivo to evaluate study endpoints. At AstraZeneca, you will have the opportunity to make a significant impact on the future of healthcare while working in a collaborative environment at the cutting edge of research. The ideal candidate will thrive in this setting and contribute to our continued growth as we build our evolving team.

Requirements

• PhD in Immunology, Aging Biology, Cell Biology, or a related field, with 3-5 years of postdoctoral or industry experience in aging biology and immunology.
• Proficiency in flow cytometry, immunological assays, and cellular and molecular biology methods; experience with in vitro and in vivo aging/immunology models.
• Deep understanding of immune cell-intrinsic versus microenvironment-driven aging mechanisms.
• Demonstrated publication record in peer-reviewed journals.
• Strong analytical abilities for complex datasets; excellent written and oral communication skills; proven collaboration in team environments; highly self-motivated and adaptable to evolving priorities.

Nice To Haves

• Prior experience with basic in vivo procedures.
• Experience in drug discovery or therapeutic development.
• Expertise working with aging-affected immune cell populations, including T cells, NK cells, and myeloid cells.
• Knowledge of immuno-oncology therapeutic strategies.
• Understanding of immune aging biomarkers and immune health assessment.

Responsibilities

• Target discovery and validation: Design and execute experiments to inform target identification and validation for age-related immune restoration.
• Aging mechanism studies: Implement experiments that distinguish immune cell-intrinsic aging from microenvironment-mediated changes.
• Strategy contribution: Contribute to the evolution of immune-aging strategy based on emerging insights and experimental findings.
• Data generation and communication: Generate high-quality data and present results to internal stakeholders and the external scientific community.
• Cross-functional teamwork: Work within multidisciplinary teams while maintaining flexibility in a dynamic research environment.
• Translational support: Collaborate with external CROs and internal in vivo pharmacology teams to support study design and evaluate in vivo endpoints through ex vivo tissue processing.

Benefits

• Competitive remuneration and benefits apply
• Competitive Total Reward program including a market driven base salary, bonus and long-term incentive.
• Generous paid time off program
• Comprehensive benefits package
• Eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles.
• Qualified retirement programs
• Paid time off (i.e., vacation, holiday, and leaves)
• Health, dental, and vision coverage in accordance with the terms of the applicable plans.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree