Senior Scientist II, Rheumatology
About The Position
The Senior Scientist II will join AbbVie’s Rheumatology team at the Cambridge Research Center within Discovery Immunology R&D. The role contributes to preclinical drug discovery programs through target validation, mechanism-of-action studies, and translational research, connecting human disease biology with preclinical approaches to inform development of potential therapies for autoimmune disease. The position applies expertise in immunology and inflammation biology, preclinical pharmacology, and in vivo model development to generate high-quality data packages that inform program decisions and advance differentiated therapeutic programs across the Immunology portfolio. The scientist leads a team of scientists and serves as a functional pharmacology representative for pipeline programs, collaborating across teams and locations.
Requirements
- Bachelor’s degree or equivalent education and typically 12 years of experience, or a master’s degree or equivalent education and typically 10 years of experience, or a Ph.D. and typically 4 years of experience.
- Proven expertise in in vitro and preclinical in vivo model systems, including hands-on preclinical pharmacology and in vivo model development experience.
- Excellent interpersonal, communication, and collaboration skills.
- Ability to work effectively in a highly collaborative environment, including with cross-functional teams and colleagues across multiple locations.
- Build strong relationships with peers and cross-functional partners to enable higher performance.
- Learn quickly, grasp the essence of a situation, and change course as needed.
- Create a learning environment that is open to suggestions and experiments to advance science.
- Embrace others’ ideas, nurture innovation, and manage innovation through to implementation.
Nice To Haves
- Experience managing research associates.
Responsibilities
- Lead a team of scientists to generate high-quality data packages supporting drug candidate advancement from lead optimization through IND filing.
- Drive in vitro and in vivo pharmacology for drug candidates, including establishing PK/PD relationships, developing and optimizing screening assays, designing and executing mechanism-of-action studies, and evaluating candidate efficacy.
- Develop acute and/or chronic murine models of inflammation relevant to rheumatological diseases, including RA, PsA, and SLE, to support preclinical candidate development.
- Apply immunological techniques including flow cytometry, PCR/gene expression analysis, protein and cytokine quantification, histopathology, and other relevant functional readouts.
- Design experiments, analyze data, and present findings at AbbVie scientific forums and external conferences.
- Author and review technical reports, protocols, and other key scientific documents.
- Represent pharmacology in pipeline programs, contributing to target evaluation, mechanism-of-action studies, and model development.
- Follow corporate standards for conduct, documentation, safety, handling materials, and humane treatment of laboratory animals.
Benefits
- Paid time off, including vacation, holidays, and sick time.
- Medical, dental, and vision insurance.
- 401(k).
- Eligible to participate in long-term incentive programs.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
