Senior Scientist I- Translational Medicine- PKS, ADME

Novartis • Cambridge, MA

44d • $89,600 - $166,400 • Onsite

About The Position

Support discovery and development projects through the design, development, and execution of in-vitro ADME assays, while building next generation lab automation capabilities to deliver high-quality study data for informed decision-making.

Requirements

• BSc or MSc with relevant experience in drug metabolism and pharmacokinetics or related field.
• BSc: 7+ years; MSc: 4+ years of ADME/DMPK experience.
• Experience working in a drug discovery or development laboratory or relevant experience in a CRO, Pharma or Biotech is highly desirable.
• Experience in metabolic stability and permeability assays highly preferrable; cell culture experience is a plus.
• Experience with laboratory automation integrated with AI-enabled analytics is highly desirable.
• Knowledge of related disciplines (e.g., bioanalytical, toxicology, biomarker) in the drug discovery or development process.
• Ability to work as part of a cross-functional team in a highly dynamic, matrixed, project-team environment.
• Strong organizational and project skills with critical thinking and problem-solving skills.
• Fluent oral and written English

Nice To Haves

• cell culture experience is a plus.

Responsibilities

• Plan, execute and report ADME assays such as metabolic stability and permeability to support PK Science’s strategies.
• Interpret in vitro ADME data and translate findings to support early discovery, compound optimization and selection.
• Contribute to novel ADME methodologies and expand assay capabilities.
• Advance automation strategies (e.g., liquid handling, assay miniaturization, assay multiplexing) to expand laboratory capacity, standardize execution to reduce manual effort, and strengthen discovery assay operations.
• Execute and/or contribute to fully automated, end-to-end ADME assay workflows integrated with AI-enabled analytics.
• Develop methods to support small and large molecule bio-analysis using LCMS-MS, HRMS, and ICP-MS techniques.
• Troubleshoot lab instrumentation and automation platforms.
• Manage study timelines, objectives and budgets, ensure accuracy of project progress in company tracking tools.
• Under management supervision, work to effectively communicate data, strategy and results to the project teams.
• Contribute to internal ADME study reports and regulatory documents (IND, IMPD, NDA, etc.).
• Participate in cross-departmental teams, department-wide initiatives and work streams.
• Complete all required organizational trainings and requirements according to corporate timelines.
• Adhere in strict accord to the appropriate SOP, quality and HSE guidelines.

Benefits

• health, life and disability benefits
• a 401(k) with company contribution and match
• generous time off package including vacation, personal days, holidays and other leaves

What This Job Offers

• Job Type: Full-time
• Career Level: Senior