Senior Research Associate or Associate Scientist, Translational Medicine

Cabaletta Bio Inc.•Philadelphia, PA

1d•Onsite

About The Position

Reporting to the Senior Scientist, Translational Medicine, Cabaletta Bio is seeking an experienced, motivated, detail-oriented, and highly skilled Senior Research Associate/Associate Scientist within its Translational Medicine team. Under scientific and technical supervision, the individual will be primarily responsible for developing and performing autoantibody evaluation assays (MSD, Luminex, ELISA) and other molecular-based assays such as dPCR. As part of the Translational Medicine team, the individual must be able to perform qualified assays on clinical trial participant materials, adhering to internal compliance standards.

Requirements

MS degree in Biology, Immunology, Engineering or related field or Bachelor’s degree with 2+ years of experience in an academic laboratory or the biotechnology industry is required.
Experience with molecular based assays such as ELISA’s, MSD, Luminex, and/or dPCR platforms.
Significant lab experience including aseptic technique, mammalian cell culture, and DNA extraction.
Must be able to follow SOPs and follow good documentation practices.
Must be highly organized and efficient, able to work independently.
Strong problem-solving skills are preferred.
Must be able to communicate clearly verbally and in writing.
Must have a desire to be part of a growing organization that uses cutting-edge science.
Strong team orientation and passion for continuous self-development.
Comfortable in a fast-paced small company environment and able to adjust workload based upon changing priorities.

Nice To Haves

Experience in protocol design, qualification, and SOP generation.
Experience with qPCR/dPCR platforms.
Experience with autoantibody evaluation assays.
Experience with clinical sample handling and inventory management is strongly preferred.
Experience troubleshooting, qualifying, or validating molecular based assays.
Experience in the biotechnology industry or in a startup industrial setting.
Previous experience with GLP/GCP & ICH regulations.
Prior use of an electronic laboratory notebook system; involvement in system development is a plus.

Responsibilities

With guidance from a Senior Scientist, Translational Medicine, perform assays on clinical samples and potentially pre-clinical samples.
Perform qualified or validated molecular based assays (Luminex, dPCR, MSD, ELISA, etc.) on clinical samples to inform on cell product persistence and efficacy in humans.
Participate in generating, qualifying, and validating GLP-like assays and contributing to the development of corresponding SOPs.
Interfacing heavily with the electronic lab notebook (eLN) system and sample management system; accurately capturing data in a timely manner, ensuring data integrity and protocol compliance using an eLN.
Maintain GDP-compliant and detailed records for clinical sample lifecycle (receipt, usage, inventory, etc.).
Involvement in clinical sample accessioning with close attention to metadata entry.
Opportunities to learn and perform cell based assays such as flow cytometry and cell killing assays.
Manage multiple internal projects / workstreams simultaneously.
Performing lab associated tasks in accordance with GLP and Cabaletta Bio lab safety policies and SOPs.
General maintenance of laboratory space and contribution to weekly activities.