Senior Scientist I, Quantitative, Translational, and ADME Sciences (QTAS)

AbbVie•Worcester, MA

14h•$96,500 - $183,500•Onsite

About The Position

The Biomarker team of Quantitative Translational ADME Science (QTAS) at AbbVie in Worcester, MA is seeking an experienced, creative, and highly motivated senior scientist to support bioanalytical method development, validation and preclinical/clinical sample testing for the discovery and development of novel therapies in multiple therapeutic areas. The Biomarker team focuses on PCR-based assays as well as ligand binding assays (LBA) to support exploratory and translational research that enables decision-making. The ideal candidate should have hands-on experience in a variety of technologies, including but not limited to qPCR, dPCR, ligand binding assays, high sensitivity and multiplex assays, sample processing and handling, etc. The candidate will be a key member of a global non-regulated bioanalysis team that support all AbbVie therapeutic areas.

Requirements

Bachelor’s Degree or equivalent education with 10 or more years of relevant experience, Master’s Degree or equivalent education with 8 or more years of relevant experience, or PhD (molecular biology, biochemistry, or other related fields, preferred).
Extensive and proven experience in PCR-based bioanalytical workflows for pre-clinical and clinical projects, especially in DNA/RNA purification and qPCR, dPCR, etc.
Proficiency with computers and data analysis/documentation software including platform specific tools, LIMS, and ELN
Working knowledge of LBA (ELISA, MSD, etc.) biomarker bioanalytical assay development, validation, and sample testing workflows to comply with current regulatory standards and best industry practices.
Excellent communication skills, and proven ability to work effectively as a member of a multidisciplinary team.
Demonstrated capacity to work in a fast-paced environment with meticulous attention to detail, and an ability to handle multiple projects, prioritize work, and meet deadlines.

Nice To Haves

Working knowledge of handling clinical samples is a plus.
Working knowledge of automation is a plus.

Responsibilities

Develop, qualify, and validate robust bioanalytical qPCR and dPCR workflows on a variety of sample matrices from a variety of species.
Experienced with various ligand binding assays on multiple analytical platforms across a variety of sample matrices.
Conduct and document appropriately compliant biomarker sample testing to support pre-clinical and clinical studies.
Plan and execute in vivo sample analysis based on bioanalytical protocol and study design.
Interpret, present, and discuss assay results; use results to guide analysis and adjust strategy. Communicate experimental plans and results effectively, both verbally and in writing during regular lab meetings and with broader teams.
Develop effective partnerships with discovery, preclinical safety, clinical pharmacology, and project team representatives in a highly collaborative and innovative environment to deliver high-impact quality data in a timely manner.
Evaluate novel, pipeline-enabling, bioanalytical technologies to expand capabilities and enhance efficiency.
Maintain timely laboratory notebooks (ELN) and LIMS records in compliance with AbbVie policies.
Strong organization and communication skills, proactive, attention to detail, critical thinking, troubleshooting skills, independence, multitasking, desire to learn new techniques, and contribute to cutting-edge projects.