Senior Director, ADME

Madrigal Pharmaceuticals•Conshohocken, PA

2d•$256,000 - $313,000

About The Position

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way. The Senior Director, ADME will provide technical leadership and execution for ADME activities supporting nonclinical and clinical development programs. This role is primarily responsible for nonclinical ADME strategy and oversight, while supporting Clinical Pharmacology and early clinical development as a subject matter expert. This individual will bring deep expertise in drug metabolism, with working knowledge across broader ADME disciplines, and will oversee all ADME studies conducted through CRO partners. The role requires strong hands-on scientific judgment to design, interpret, and integrate ADME data to support program decisions and regulatory submissions.

Requirements

Ph.D. in Pharmacokinetics, Drug Metabolism, Pharmaceutical Sciences, or related discipline (or equivalent experience)
15+ years of ADME experience in pharmaceutical or biotechnology drug development
Experience supporting both nonclinical and clinical programs
Deep expertise in drug metabolism (required)
Working knowledge of transporters and broader ADME sciences
Strong experience designing and interpreting ADME studies
Strong scientific judgment and attention to detail
Hands-on, execution-focused approach
Effective communicator within technical and cross-functional teams
Ability to operate in a fast-paced, dynamic environment

Nice To Haves

Experience with PBPK modeling and human ADME (mass balance) studies preferred

Responsibilities

Serve as the ADME subject matter expert, with deep expertise in metabolism
Define and execute ADME strategies in collaboration with functional area leads
Design, oversee, and interpret nonclinical ADME studies (in vitro and in vivo)
Manage CROs, including vendor selection, study design, protocol development, and report review
Ensure ADME data are scientifically sound and aligned with regulatory expectations
Support clinical development through ADME input, including DDI risk assessment, PBPK modeling, and human ADME (mass balance) study design and interpretation
Integrate nonclinical and emerging clinical PK data to inform ADME strategy and study design
Author and review ADME sections of regulatory submissions (IND/CTA, NDA) and support regulatory interactions