Senior Scientist (I/O) In Vitro/Ex Vivo

ModeX Therapeutics • Weston, MA

11d • Onsite

About The Position

ModeX Therapeutics is seeking a highly skilled and motivated Senior Scientist with strong hands-on experience in Immuno-oncology/Immunology to support the development and progression of novel immune therapies. The successful candidate will design, execute, and interpret cell-based studies using primary immune cells and relevant assay systems to evaluate biologic drug candidates, characterize their mechanism of action, and address biological questions. This is an exciting opportunity for a collaborative scientist who enjoys working at the bench, brings strong biological insight, and wants to contribute to the development of next-generation therapeutics in a fast-paced, rapidly growing biotech company with a bold vision.

Requirements

• Ph.D. or M.S. Degree in Immunology, Cancer Biology, Cell biology, Immuno-oncology, or a related scientific field, with 10+ years of relevant research experience, including at least 4+ years in a biotech or pharmaceutical R&D environment
• Strong, hands-on expertise in Immunotherapy and Immunology, with the ability to independently evaluate and apply new concepts and immunoassays
• Demonstrated experience designing, executing, and interpreting functional assays using primary immune cells, including multi-parameter flow cytometry, cytokine profiling (ELISA, MSD, Luminex, or equivalent), immune activation, proliferation, and cytotoxicity assays.
• Hands-on experience with flow cytometry panel design, optimization, and data analysis
• Proven ability to work independently, prioritize effectively, and drive projects forward in a fast-paced biotech environment
• Excellent written and oral communication skills, including the ability to present complex data clearly to scientific and cross-functional audiences
• Strong troubleshooting, organization, data analysis, and problem-solving skills
• Highly collaborative mindset with the ability to contribute ideas, work across teams, and mentor junior team members as needed

Nice To Haves

• spectral flow cytometry experience is desirable

Responsibilities

• Play a key role in the development of new biologic drugs for Immunotherapy and Immunology
• Independently design, execute, analyze, and interpret in vitro/ex vivo studies to characterize drug candidates and their mechanisms of action
• Develop and perform complex immune cell-based functional assays using primary immune cells (human and mouse), tumor cell lines, reporter systems, and co-culture models
• Design, optimize and troubleshoot multicolor flow cytometry panels, including compensation/unmixing, antibody titration and gating strategies
• Analyze experimental data, generate clear conclusions, and provide data-driven recommendations to advance research programs
• Collaborate cross-functionally with discovery, translational and project teams to ensure data-driven decision-making and timely progression of programs.
• Contribute to scientific reports, presentations, and project updates, and effectively communicate findings to cross-functional teams
• Maintain accurate documentation of experimental activities and ensure compliance with applicable laboratory standards and data integrity practices.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree