Senior Scientist I, DMPK

Wave Life Sciences • Lexington, MA

49d • Hybrid

About The Position

Wave Life Sciences is seeking a highly motivated and detail-oriented Scientist with strong expertise in bioanalytical and Drug Metabolism and Pharmacokinetics (DMPK) sciences to support drug development programs from preclinical through clinical stages. The successful candidate will play a key role in independently designing, executing, and interpreting pharmacokinetic (PK), toxicokinetic (TK), plasma protein binding and in vitro drug-drug interaction (DDI) studies. This role will be based in our Lexington, MA office with a hybrid work arrangement.

Requirements

• Ph.D. in Pharmacokinetics, Pharmaceutical Sciences, Biochemistry, or related discipline with at least 3 years of relevant experience, or M.S. with at least 6 years of industry experience
• Proficient in PK software tools such as Phoenix WinNonlin and conduct NCA
• Conduct graphical analysis using standard tools like Phoenix WinNonlin, R, or similar
• Demonstrate sound knowledge of PK/PD principles
• Familiarity with regulatory requirements for nonclinical DMPK studies
• Demonstrate expertise in plasma protein binding and in vitro DDI assessments (e.g., CYP inhibition/induction, transporter interactions)
• Ability to innovate and think creatively to support the drug development process
• Excellent communication, organizational, and teamwork skills
• Knowledge and experience in bioanalysis to support DMPK studies (metabolite identification, biodistribution, etc.)

Nice To Haves

• Experience supporting the development of RNA-based modalities (e.g., siRNA, antisense oligonucleotides, GalNAc conjugates, etc.)
• Hands-on experience with modeling and simulation is a plus

Responsibilities

• Independently design, execute, and interpret in vitro and in vivo studies (i.e., ADME, PK, PK/PD) to support advancement of RNA therapeutic programs
• Autonomously analyze and interpret PK, TK and PK/PD data using appropriate software tools (e.g., Phoenix WinNonlin), including conducting NCA and graphical exposure-response analyses
• Represent DMPK function at cross-functional project team meetings
• With guidance, plan, execute, and deliver DMPK deliverables from lead selection to IND stage
• Collaborate with cross-functional teams including bioanalysis, discovery research, toxicology, clinical pharmacology, regulatory, and external CROs to meet program goals and timelines
• Prepare high-quality scientific reports and integrate DMPK data into regulatory documents (IND, CTA, briefing documents, etc.)
• Manage internal and external (CRO) DMPK activities including DDI, PPB, to ensure timely delivery of high-quality data
• Deliver robust IND/CTA-enabling DMPK packages to support regulatory filings
• Stay current with regulatory guidance and scientific advances in the field of bioanalysis and DMPK

Benefits

• company-sponsored medical, dental, vision, life, long and short-term disability insurances
• generous paid time off (including a week-long company shutdown in the Summer and the Winter)
• 401K participation with matching contributions
• Employee Stock Purchase Program

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree