Senior Scientist I, Biology

Novartis•Cambridge, MA

1d•$93,800 - $174,200•Onsite

About The Position

The Novartis Biomedical Research Oncology Disease Area is seeking an experienced scientist to join the Target Biology and Discovery (TBaD) group. The mission of our group is to uncover novel therapeutic targets and effective modalities to benefit cancer patients. By leveraging cutting-edge technologies, innovative screening approaches, and in-depth mechanistic studies, the team initiates the crucial first steps in bringing new oncology medicines to the clinic.

Requirements

B.S or M.S. in Biochemistry, Molecular Biology, Cell Biology, Cancer Biology or related field.
Strong proficiency in mammalian cell culture, molecular biology (vector design, cloning), protein analysis workflows (e.g. Western blotting, FACS), and CRISPR-based gene editing technologies (e.g. base editing, prime editing, CRISPRi, CRISPRa, etc.).
Experience performing chromatin-based experiments.
Clear track record of working efficiently with teams.
Strong interpersonal, organizational and communication skills, with a commitment to fostering a collaborative and innovative work environment.
Ability to manage multiple projects simultaneously and deliver high-quality results.
A creative, curious, passionate, and scientifically fearless mindset dedicated to improving the lives of patients.
Demonstrates strong critical thinking and independent problem-solving skills.

Nice To Haves

Proficiency with data mining, computational skills, and chromatin-based analyses.
Previous research related to hormone driven cancer cell biology (e.g. prostate and breast cancer).

Responsibilities

Lead mechanism‑of‑action studies using advanced cell biology and chromatin biology approaches to interrogate therapeutic response.
Design, develop, and execute in vitro assays to elucidate key aspects of cancer biology.
Leverage state-of-the-art genome-editing tools to perform genetic screens and support compound mechanism-of-action studies.
Design, execute, analyze, document experiments, and communicate results in team settings.
Stay current with scientific literature and advancements.
Collaborate across departments and with external partners to foster growth and innovation within the team and department, and contribute to the culture of the group, are key aspects of this role.