Senior Scientist, High Throughput Protein Production and Engineering

Bristol Myers Squibb • Brisbane, CA

1d • Onsite

About The Position

We are seeking a highly motivated Senior Scientist to join our Discovery Biotherapeutics organization in Brisbane, CA. This role will lead and advance a high‑throughput, automated mammalian antibody expression capability within Discovery Biotherapeutics. The Senior Scientist will develop, deploy, and operate automation‑enabled platforms that accelerate antibody discovery and engineering, including complex and multispecific biologics. Working at the interface of mammalian expression biology, laboratory automation, software‑enabled workflows, and protein engineering, this position enables scalable, integrated discovery approaches that increase speed and impact across early biologics programs. The lab-facing role offers an exciting opportunity to make a meaningful scientific contribution in support of BMS’s mission of delivering innovative medicines to patients.

Requirements

• PhD in Bioengineering, Structural Biology, Biochemistry, Molecular Biology, or related field with 2+ years; or MS with 5+ years; or BS with 7+ years of pharmaceutical R&D or related industry experience.
• Senior-level experience in mammalian antibody expression and protein engineering in discovery or early development environments.
• Proven experience developing and operating high-throughput, automated expression workflows.
• Strong understanding of HEK293, CHO, CFE or equivalent expression systems and associated challenges.
• Advanced understanding of laboratory automation, key standardized instrumentation (e.g. Lynx, PHERAstar, WELLJET, F.A.S.T., I.DOT), automation scheduling software (e.g. Momentum, Cellario) and programming skills (e.g. C#)
• Strong interpersonal skills and ability to work independently while influencing cross-functional discovery biotherapeutics, biology, automation, and engineering teams.
• Excellent written and verbal communication skills.

Nice To Haves

• Experience with machine-learining and/or closed-loop workflows is a plus.

Responsibilities

• Lead discovery-stage mammalian expression of antibodies and antibody-derived formats, including IgGs, fragments, and multispecific biologics.
• Apply protein engineering principles to the design and optimization of expression constructs.
• Design, operate, and continuously improve high-throughput, automation-ready expression and purification workflows.
• Implement miniaturized, plate-based, and modular expression systems optimized for rapid discovery throughput.
• Partner with automation teams to integrate liquid handling, incubators, culture handling, and downstream processing steps.
• Develop python and C#-based tools for workflow orchestration, automation control and data capture.
• Interface with laboratory software platforms to ensure high-quality, traceable data generation compatible with computational and ML-driven discovery.
• Collaborate with AI/ML, binder discovery, molecular interaction, and functional assay teams to support binder discovery campaigns.

Benefits

• Health Coverage: Medical, pharmacy, dental, and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees)
• Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
• Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.
• All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree