Scientist, High-Throughput Biology

Alnylam Pharmaceuticals•Cambridge, MA

1d•Onsite

About The Position

We are seeking a highly motivated scientist to join our High Throughput In Vitro Screening team. This role will lead the in vitro screening workflow to generate high-quality, decision-enabling data across multiple programs. This is a hands-on, in-lab role. The candidate is expected to contribute at the bench, partnering with associates and scientists to execute and troubleshoot experiments. This position is onsite and will be primarily located in Cambridge, MA.

Requirements

Ph.D. with 2+ years, or M.S. with 5+ years of industry experience in molecular biology, pharmacology, or a related field
Experience in high-throughput screening and assay development in a drug discovery setting
Experience with RNAi, ASO, or other oligonucleotide-based therapeutics
Design, optimize, and execute high-throughput in vitro assays (e.g., transfection, free uptake, qPCR/TaqMan, reporter assays) across diverse cell types
Strong understanding of transfection and free-uptake systems across suspension and adherent cell models, including primary systems
Hands-on experience with laboratory automation platforms and scaling high-throughput operations
Familiarity with automated data capture and analysis platforms
Proven track record of delivering high-quality, reproducible data under tight timelines to inform decisions
Demonstrated experience mentoring scientists and leading complex workflows
Strong communication skills; able to provide clear, timely updates on program progress and key lab activities
Comfortable working at the bench alongside associates to execute and troubleshoot experiments
Demonstrated success leading cross-functional initiatives and driving operational improvements

Responsibilities

Lead, mentor, and develop scientists to foster a high-performing, collaborative team
Drive end-to-end in vitro screening workflows, from assay development through data delivery, to enable timely, data-driven lead selection
Design, optimize, and execute high-throughput assays (e.g., transfection, free uptake, qPCR/TaqMan, reporter assays) across diverse cell types
Partner with automation and engineering teams to expand and optimize automated workflows, improving throughput, robustness, and operational efficiency
Set and maintain high standards for data quality and reproducibility using assay metrics, controls, and QC frameworks
Identify and implement workflow improvements to accelerate timelines, increase throughput, and enhance data quality
Manage multiple programs in parallel, aligning priorities, timelines, and deliverables in a dynamic, matrixed environment