Research Scientist II, Cell Biologist/High Throughput Screening

The Broad Institute•Cambridge, MA

22h•Onsite

About The Position

We're looking for a passionate and skilled Cell Biologist with High Throughput Screening experience to join our CDoT Collaborative Screening team. Reporting to an Associate Director, you'll be a key member of our multidisciplinary teams, helping to drive the development and execution of predominantly cell-based high throughput screens. Your work will directly empower target validation, assay development, hit discovery and validation. Ideally, you have experience with a variety of assay formats within a drug discovery or therapeutics context.

Requirements

PhD degree with 5-7 year’s experience in cell biology, chemical biology, or high throughput screening
Demonstrated in-depth experience in culturing, deriving, and maintaining various cell lines.
Proven ability to work both collaboratively within a team and independently to meet project goals; makes data-driven decisions for forward progress
Maintain detailed experimental records, documentation, and written protocols
Excellent communication, organization, and time management skills.
Must show strong ability to be flexible, to adapt and effectively manage changes in a fast-paced dynamic environment and troubleshoot.

Nice To Haves

Experience with the development and execution of plate-based assays, such as Cell Titer-Glo viability assay, immunofluorescence staining and biochemical assays, as well as high-throughput screening and automation.
Experience with advanced techniques such as high-content imaging or molecular biology (e.g., qPCR, western blotting, ELISA).
Experience with FLIPR (Fluorescence Imaging Plate Reader) assays to measure intracellular calcium flux, membrane potential, and ion channel activity.
Ability to mentor junior trainees.

Responsibilities

Independently design and execute cell-based assays for drug discovery projects, including both genetic and small molecule screening in various high throughput formats.
Culture and maintain diverse cell lines and primary cells with a high degree of precision.
Collaborate, coordinate and communicate with cross-functional teams to advance therapeutic projects and ensure that research plans, timelines, and deliverables are met.
Analyze, interpret, explain and present experimental data, research plans and results to both internal teams and external collaborators.
Innovate new cellular assay methods and contribute to a fast-paced, dynamic research environment.
Supervise, train and mentor junior members of the team.